Stadium: Drake Stadium Round: 1
Home Manager: Todd Stepsis Away Manager: Glenn Caruso
| NCAAF | 2021/11/06 17:00 | St. Thomas (MN) v Davidson Wildcats | L | 15-42 |
| NCAAF | 2021/10/30 18:00 | Marist v St. Thomas (MN) | W | 7-27 |
| NCAAF | 2021/10/16 17:00 | St. Thomas (MN) v Stetson Hatters | W | 38-7 |
| NCAAF | 2021/10/09 18:00 | Valparaiso v St. Thomas (MN) | W | 13-20 |
| NCAAF | 2021/10/02 20:00 | St. Thomas (MN) v San Diego | L | 24-27 |
| NCAAF | 2021/09/25 17:00 | Butler v St. Thomas (MN) | W | 0-36 |
| NCAAF | 2021/09/11 17:10 | Michigan Technological University Huskies v St. Thomas (MN) | W | 9-12 |
| NCAAF | 2019/11/16 19:00 | St. Thomas (MN) v Bethel Royals | W | 17-7 |
| NCAAF | 2021/11/06 16:00 | Drake Bulldogs v Marist | L | 0-7 |
| NCAAF | 2021/10/16 21:00 | Drake Bulldogs v San Diego | L | 10-13 |
| NCAAF | 2021/10/09 17:00 | Dayton v Drake Bulldogs | L | 28-10 |
| NCAAF | 2021/10/02 16:00 | Drake Bulldogs v Butler | W | 6-3 |
| NCAAF | 2021/09/25 17:00 | Valparaiso v Drake Bulldogs | L | 24-21 |
| NCAAF | 2021/09/18 21:00 | Drake Bulldogs v North Dakota | L | 0-38 |
| NCAAF | 2021/09/12 00:00 | Drake Bulldogs v Montana State | L | 7-45 |
| NCAAF | 2021/09/02 23:00 | Drake Bulldogs v W. Virginia Bobcats | W | 45-3 |