Stadium: Arthur J. Rooney Athletic Field Round: 1
Home Manager: Jerry Schmitt Away Manager:
| NCAAF | 2021/09/11 18:00 | Duquesne v Ohio | W | 28-26 |
| NCAAF | 2021/09/05 00:00 | Duquesne v TCU | L | 3-45 |
| NCAAF | 2021/04/11 18:00 | Sacred Heart v Duquesne | L | 34-27 |
| NCAAF | 2021/03/28 16:00 | Duquesne v Bryant | W | 20-10 |
| NCAAF | 2021/03/21 16:00 | LIU Brooklyn v Duquesne | W | 17-35 |
| NCAAF | 2021/03/14 16:00 | Duquesne v Wagner | W | 17-0 |
| NCAAF | 2021/03/07 17:00 | Sacred Heart v Duquesne | W | 27-30 |
| NCAAF | 2019/11/23 17:00 | Central Connecticut v Duquesne | L | 43-10 |
| NCAAF | 2021/09/18 22:00 | Virginia Union Panthers v Lynchburg Dragons | L | 49-7 |
| NCAAF | 2021/09/09 23:00 | Mars Hill Lions v Lynchburg Dragons | L | 50-14 |
| NCAAF | 2021/09/04 16:00 | Virginia Wise Highland Cavaliers v Lynchburg Dragons | L | 54-0 |
| NCAAF | 2019/11/16 18:00 | Morgan State v Lynchburg Dragons | L | 59-26 |
| NCAAF | 2019/11/09 22:00 | Southern v Lynchburg Dragons | L | 58-7 |
| NCAAF | 2019/10/26 18:00 | Hampton v Lynchburg Dragons | L | 56-6 |
| NCAAF | 2019/10/19 19:00 | Prairie View v Lynchburg Dragons | L | 51-0 |
| NCAAF | 2019/10/05 20:00 | Mississippi Valley State v Lynchburg Dragons | L | 31-23 |