Stadium: Campus Field Round: 1
Home Manager: Mark Nofri Away Manager: Jerry Schmitt
| NCAAF | 2021/04/11 18:00 | Sacred Heart v Duquesne | L | 34-27 |
| NCAAF | 2021/03/07 17:00 | Sacred Heart v Duquesne | W | 27-30 |
| NCAAF | 2019/10/19 16:00 | Duquesne v Sacred Heart | W | 20-6 |
| NCAAF | 2018/11/10 17:00 | Duquesne v Sacred Heart | W | 28-24 |
| NCAAF | 2017/10/28 16:00 | Sacred Heart v Duquesne | W | 21-37 |
| NCAAF | 2021/10/09 16:00 | Bryant v Duquesne | W | 34-39 |
| NCAAF | 2021/10/02 17:00 | Duquesne v Merrimack | W | 37-14 |
| NCAAF | 2021/09/25 17:00 | Duquesne v Lynchburg Dragons | W | 56-7 |
| NCAAF | 2021/09/11 18:00 | Duquesne v Ohio | W | 28-26 |
| NCAAF | 2021/09/05 00:00 | Duquesne v TCU | L | 3-45 |
| NCAAF | 2021/04/11 18:00 | Sacred Heart v Duquesne | L | 34-27 |
| NCAAF | 2021/03/28 16:00 | Duquesne v Bryant | W | 20-10 |
| NCAAF | 2021/03/21 16:00 | LIU Brooklyn v Duquesne | W | 17-35 |
| NCAAF | 2021/10/16 17:00 | Central Connecticut v Sacred Heart | W | 17-27 |
| NCAAF | 2021/10/09 18:00 | Merrimack v Sacred Heart | W | 10-20 |
| NCAAF | 2021/10/02 17:00 | Sacred Heart v Howard | L | 17-22 |
| NCAAF | 2021/09/25 17:30 | Sacred Heart v Dartmouth | L | 3-41 |
| NCAAF | 2021/09/18 17:00 | Morgan State v Sacred Heart | W | 7-21 |
| NCAAF | 2021/09/11 23:00 | Sacred Heart v Bryant | L | 6-17 |
| NCAAF | 2021/09/04 22:00 | Bucknell v Sacred Heart | W | 0-21 |
| NCAAF | 2021/04/24 23:00 | Sacred Heart v Delaware | L | 10-19 |