Stadium: O'Shaughnessy Stadium Round: 1
Home Manager: Glenn Caruso Away Manager:
| NCAAF | 2021/11/13 18:00 | Marist v Presbyterian | L | 57-32 |
| NCAAF | 2021/11/06 18:00 | Presbyterian v Valparaiso | L | 55-65 |
| NCAAF | 2021/10/30 17:00 | Stetson Hatters v Presbyterian | L | 56-14 |
| NCAAF | 2021/10/23 17:00 | San Diego v Presbyterian | L | 69-28 |
| NCAAF | 2021/10/16 23:00 | Presbyterian v Davidson Wildcats | L | 35-70 |
| NCAAF | 2021/10/09 17:00 | Morehead State v Presbyterian | L | 38-30 |
| NCAAF | 2021/09/25 17:00 | Presbyterian v Dayton | L | 43-63 |
| NCAAF | 2021/09/18 22:00 | Presbyterian v Campbell | L | 0-72 |
| NCAAF | 2021/11/13 18:00 | St.Thomas MIN v Drake Bulldogs | W | 21-14 |
| NCAAF | 2021/11/06 17:00 | St.Thomas MIN v Davidson Wildcats | L | 15-42 |
| NCAAF | 2021/10/30 18:00 | Marist v St.Thomas MIN | W | 7-27 |
| NCAAF | 2021/10/16 17:00 | St.Thomas MIN v Stetson Hatters | W | 38-7 |
| NCAAF | 2021/10/09 18:00 | Valparaiso v St.Thomas MIN | W | 13-20 |
| NCAAF | 2021/10/02 20:00 | St.Thomas MIN v San Diego | L | 24-27 |
| NCAAF | 2021/09/25 17:00 | Butler v St.Thomas MIN | W | 0-36 |
| NCAAF | 2021/09/11 17:10 | Michigan Technological University Huskies v St.Thomas MIN | W | 9-12 |