Stadium: William H. Greene Stadium Round: 1
Home Manager: Larry Scott Away Manager: Mark Nofri
| NCAAF | 2021/09/25 17:30 | Sacred Heart v Dartmouth | L | 3-41 |
| NCAAF | 2021/09/18 17:00 | Morgan State v Sacred Heart | W | 7-21 |
| NCAAF | 2021/09/11 23:00 | Sacred Heart v Bryant | L | 6-17 |
| NCAAF | 2021/09/04 22:00 | Bucknell v Sacred Heart | W | 0-21 |
| NCAAF | 2021/04/24 23:00 | Sacred Heart v Delaware | L | 10-19 |
| NCAAF | 2021/04/11 18:00 | Sacred Heart v Duquesne | W | 34-27 |
| NCAAF | 2021/03/21 17:00 | Merrimack v Sacred Heart | W | 9-26 |
| NCAAF | 2021/03/14 17:00 | LIU Brooklyn v Sacred Heart | W | 7-35 |
| NCAAF | 2021/09/25 16:00 | Howard v Robert Morris | L | 16-22 |
| NCAAF | 2021/09/18 16:00 | Hampton v Howard | L | 48-32 |
| NCAAF | 2021/09/11 23:30 | Howard v Maryland | L | 0-62 |
| NCAAF | 2021/09/04 18:00 | Howard v Richmond | L | 14-38 |
| NCAAF | 2021/04/03 17:00 | Delaware State v Howard | L | 37-28 |
| NCAAF | 2021/02/27 17:00 | Howard v Delaware State | L | 10-17 |
| NCAAF | 2019/11/23 18:00 | Morgan State v Howard | W | 15-20 |
| NCAAF | 2019/11/16 21:00 | Howard v Florida A&M | L | 7-39 |