Stadium: Carl Smith Stadium Round: 1
| NCAAF | 2021/11/06 17:00 | Catawba College v Virginia Wise Highland Cavaliers | W | 7-30 |
| NCAAF | 2021/10/30 20:00 | Limestone Saints v Virginia Wise Highland Cavaliers | W | 24-28 |
| NCAAF | 2021/10/23 16:00 | Virginia Wise Highland Cavaliers v Wingate Bulldogs | L | 21-48 |
| NCAAF | 2021/10/16 17:30 | Tusculum Pioneers v Virginia Wise Highland Cavaliers | L | 37-21 |
| NCAAF | 2021/10/09 16:00 | Virginia Wise Highland Cavaliers v Newberry Wolves | L | 14-37 |
| NCAAF | 2021/10/02 18:00 | Virginia Wise Highland Cavaliers v Lenoir Rhyne Bears | W | 35-28 |
| NCAAF | 2021/09/25 16:00 | Virginia Wise Highland Cavaliers v Carson–Newman Eagles | W | 33-7 |
| NCAAF | 2021/09/18 17:00 | Mars Hill Lions v Virginia Wise Highland Cavaliers | L | 44-9 |
| NCAAF | 2021/11/06 20:00 | Barton Bulldogs v Lenoir Rhyne Bears | L | 20-56 |
| NCAAF | 2021/10/30 18:00 | Barton Bulldogs v Bluefield College Rams | W | 62-7 |
| NCAAF | 2021/10/30 18:00 | Barton Bulldogs v Bluefield State | W | 62-7 |
| NCAAF | 2021/10/23 18:00 | Tusculum Pioneers v Barton Bulldogs | L | 41-17 |
| NCAAF | 2021/10/16 22:00 | Barton Bulldogs v Wingate Bulldogs | W | 26-20 |
| NCAAF | 2021/10/09 17:30 | Mars Hill Lions v Barton Bulldogs | L | 40-32 |
| NCAAF | 2021/10/02 18:00 | Barton Bulldogs v Carson–Newman Eagles | W | 31-17 |
| NCAAF | 2021/09/25 23:00 | Limestone Saints v Barton Bulldogs | W | 7-45 |