Round: 1
| NCAAF | 2021/10/30 18:00 | Barton Bulldogs v Bluefield State | W | 62-7 |
| NCAAF | 2021/10/30 18:00 | Barton Bulldogs v Bluefield College Rams | W | 62-7 |
| NCAAF | 2021/10/23 18:00 | Tusculum Pioneers v Barton Bulldogs | L | 41-17 |
| NCAAF | 2021/10/16 22:00 | Barton Bulldogs v Wingate Bulldogs | W | 26-20 |
| NCAAF | 2021/10/09 17:30 | Mars Hill Lions v Barton Bulldogs | L | 40-32 |
| NCAAF | 2021/10/02 18:00 | Barton Bulldogs v Carson–Newman Eagles | W | 31-17 |
| NCAAF | 2021/09/25 23:00 | Limestone Saints v Barton Bulldogs | W | 7-45 |
| NCAAF | 2021/09/18 17:00 | Catawba College v Barton Bulldogs | L | 17-10 |
| NCAAF | 2021/10/30 22:00 | Wingate Bulldogs v Lenoir Rhyne Bears | W | 6-31 |
| NCAAF | 2021/10/23 18:00 | Lenoir Rhyne Bears v Limestone Saints | W | 45-3 |
| NCAAF | 2021/10/16 17:00 | Carson–Newman Eagles v Lenoir Rhyne Bears | W | 0-59 |
| NCAAF | 2021/10/09 18:00 | Lenoir Rhyne Bears v Tusculum Pioneers | W | 38-31 |
| NCAAF | 2021/10/02 18:00 | Virginia Wise Highland Cavaliers v Lenoir Rhyne Bears | L | 35-28 |
| NCAAF | 2021/09/25 22:00 | Lenoir Rhyne Bears v Mars Hill Lions | W | 31-16 |
| NCAAF | 2021/09/18 22:00 | Newberry Wolves v Lenoir Rhyne Bears | L | 28-21 |
| NCAAF | 2021/09/04 22:00 | Virginia State Trojans v Lenoir Rhyne Bears | W | 7-48 |