[12] Santa Clara 0-5 Benfica [1] 2021-09-11 17:00
Stadium: Estadio de Sao Miguel Round: 5
Referee: Rui Manuel Gomes da Costa Home Manager: Daniel Ramos Away Manager: Jorge Jesus
Head to Head
| Portugal Primeira Liga | 2021/04/26 18:00 | Benfica v Santa Clara | L | 2-1 |
| Portugal Primeira Liga | 2021/01/04 17:00 | Santa Clara v Benfica | D | 1-1 |
| Portugal Primeira Liga | 2020/06/23 18:15 | Benfica v Santa Clara | W | 3-4 |
| Portugal Primeira Liga | 2019/11/09 18:00 | Santa Clara v Benfica | L | 1-2 |
| Portugal Primeira Liga | 2019/05/18 17:30 | Benfica v Santa Clara | L | 4-1 |
| Portugal Primeira Liga | 2019/01/11 19:00 | Santa Clara v Benfica | L | 0-2 |
Home History
| Portugal Primeira Liga | 2021/08/29 19:30 | Santa Clara v Gil Vicente | W | 1-0 |
| UEFA Conference League Qualifying | 2021/08/26 19:00 | Partizan Belgrade v Santa Clara | L | 2-0 |
| Portugal Primeira Liga | 2021/08/23 20:15 | Boavista v Santa Clara | L | 2-0 |
| UEFA Conference League Qualifying | 2021/08/19 20:30 | Santa Clara v Partizan Belgrade | W | 2-1 |
| Portugal Primeira Liga | 2021/08/15 19:30 | Santa Clara v Moreirense | D | 2-2 |
| UEFA Conference League Qualifying | 2021/08/12 18:00 | Olimpija Ljubljana v Santa Clara | W | 0-1 |
| Portugal Primeira Liga | 2021/08/08 14:30 | Tondela v Santa Clara | L | 3-0 |
| UEFA Conference League Qualifying | 2021/08/05 20:30 | Santa Clara v Olimpija Ljubljana | W | 2-0 |
Away History
| Portugal Primeira Liga | 2021/08/29 17:00 | Benfica v Tondela | W | 2-1 |
| UEFA Champions League Qualifying | 2021/08/24 19:00 | PSV v Benfica | D | 0-0 |
| Portugal Primeira Liga | 2021/08/21 17:00 | Gil Vicente v Benfica | W | 0-2 |
| UEFA Champions League Qualifying | 2021/08/18 19:00 | Benfica v PSV | W | 2-1 |
| Portugal Primeira Liga | 2021/08/14 17:00 | Benfica v Arouca | W | 2-0 |
| UEFA Champions League Qualifying | 2021/08/10 19:00 | Benfica v Spartak Moscow | W | 2-0 |
| Portugal Primeira Liga | 2021/08/07 17:00 | Moreirense v Benfica | W | 1-2 |
| UEFA Champions League Qualifying | 2021/08/04 17:00 | Spartak Moscow v Benfica | W | 0-2 |