Stadium: Knight Stadium Round: 1
| NCAAF | 2021/09/11 17:00 | Southern Virginia Knights v Bridgewater Eagles | L | 17-35 |
| NCAAF | 2021/09/04 17:30 | Wilmington Quakers v Southern Virginia Knights | W | 34-41 |
| NCAAF | 2019/11/16 18:00 | Southern Virginia Knights v The Apprentice School Builders | W | 40-7 |
| NCAAF | 2019/11/09 18:00 | Washington And Lee Generals v Southern Virginia Knights | L | 28-7 |
| NCAAF | 2019/11/02 17:00 | Southern Virginia Knights v Guilford Quakers | W | 30-17 |
| NCAAF | 2019/10/26 17:00 | Ferrum Panthers v Southern Virginia Knights | L | 31-28 |
| NCAAF | 2019/10/19 17:00 | Southern Virginia Knights v Randolph Macon Yellow Jackets | L | 27-47 |
| NCAAF | 2019/10/12 17:00 | Southern Virginia Knights v Emory And Henry Wasps | L | 14-56 |
| NCAAF | 2021/09/11 18:00 | Lagrange Panthers v Berry Vikings | L | 21-34 |
| NCAAF | 2021/09/04 23:00 | Birmingham Southern Panthers v Lagrange Panthers | L | 42-17 |
| NCAAF | 2019/11/16 18:00 | Lagrange Panthers v Huntingdon Hawks | L | 21-45 |
| NCAAF | 2019/11/09 18:00 | Methodist Monarchs v Lagrange Panthers | L | 37-33 |
| NCAAF | 2019/11/02 18:00 | Lagrange Panthers v Brevard Tornados | L | 3-21 |
| NCAAF | 2019/10/26 17:00 | Maryville Scots v Lagrange Panthers | L | 28-10 |
| NCAAF | 2019/10/19 18:00 | Lagrange Panthers v Greensboro Pride | W | 40-23 |
| NCAAF | 2019/10/12 17:00 | Averett Cougars v Lagrange Panthers | L | 55-7 |