Stadium: Lloyd L. Thornton Stadium Round: 1
| NCAAF | 2019/10/26 17:00 | Maryville Scots v Lagrange Panthers | W | 28-10 |
| NCAAF | 2018/10/20 18:00 | Lagrange Panthers v Maryville Scots | W | 17-37 |
| NCAAF | 2021/10/16 16:00 | Nc Wesleyan Battling Bishops v Maryville Scots | W | 26-31 |
| NCAAF | 2021/10/09 18:00 | Brevard Tornados v Maryville Scots | L | 31-0 |
| NCAAF | 2021/10/02 17:00 | Maryville Scots v Southern Virginia Knights | W | 38-17 |
| NCAAF | 2021/09/25 22:00 | Averett Cougars v Maryville Scots | L | 47-10 |
| NCAAF | 2021/09/18 17:00 | Maryville Scots v Methodist Monarchs | L | 21-38 |
| NCAAF | 2021/09/11 17:00 | Maryville Scots v Centre Colonels | L | 21-40 |
| NCAAF | 2021/09/04 22:00 | Berry Vikings v Maryville Scots | L | 20-14 |
| NCAAF | 2019/11/16 17:00 | Nc Wesleyan Battling Bishops v Maryville Scots | L | 23-0 |
| NCAAF | 2021/10/16 20:00 | Lagrange Panthers v Brevard Tornados | L | 10-20 |
| NCAAF | 2021/10/09 17:00 | Methodist Monarchs v Lagrange Panthers | L | 34-17 |
| NCAAF | 2021/09/25 17:00 | Lagrange Panthers v Nc Wesleyan Battling Bishops | L | 21-26 |
| NCAAF | 2021/09/18 17:00 | Southern Virginia Knights v Lagrange Panthers | W | 34-38 |
| NCAAF | 2021/09/11 18:00 | Lagrange Panthers v Berry Vikings | L | 21-34 |
| NCAAF | 2021/09/04 23:00 | Birmingham Southern Panthers v Lagrange Panthers | L | 42-17 |
| NCAAF | 2019/11/16 18:00 | Lagrange Panthers v Huntingdon Hawks | L | 21-45 |
| NCAAF | 2019/11/09 18:00 | Methodist Monarchs v Lagrange Panthers | L | 37-33 |