Stadium: Gesling Stadium Round: 1
| NCAAF | 2019/11/16 18:00 | Carnegie Mellon Tartans v Case Western Reserve Spartans | W | 24-21 |
| NCAAF | 2018/11/10 22:30 | Case Western Reserve Spartans v Carnegie Mellon Tartans | W | 23-29 |
| NCAAF | 2021/11/06 17:00 | Carnegie Mellon Tartans v Washington And Jefferson Presidents | W | 27-11 |
| NCAAF | 2021/10/30 17:00 | St Vincent Bearcats v Carnegie Mellon Tartans | W | 7-34 |
| NCAAF | 2021/10/23 17:00 | Carnegie Mellon Tartans v Thiel Tomcats | W | 53-0 |
| NCAAF | 2021/10/09 23:00 | Carnegie Mellon Tartans v Westminster Titans | W | 34-10 |
| NCAAF | 2021/10/02 17:00 | Bethany Bison v Carnegie Mellon Tartans | W | 7-47 |
| NCAAF | 2021/09/25 23:00 | Carnegie Mellon Tartans v Waynesburg Yellow Jackets | W | 39-3 |
| NCAAF | 2021/09/18 17:00 | Grove City Wolverines v Carnegie Mellon Tartans | L | 13-6 |
| NCAAF | 2021/09/11 23:30 | Geneva Golden Tornadoes v Carnegie Mellon Tartans | W | 17-31 |
| NCAAF | 2021/11/06 17:00 | Case Western Reserve Spartans v Grove City Wolverines | W | 35-21 |
| NCAAF | 2021/10/30 17:00 | Thiel Tomcats v Case Western Reserve Spartans | W | 12-30 |
| NCAAF | 2021/10/23 17:30 | Case Western Reserve Spartans v Geneva Golden Tornadoes | W | 42-38 |
| NCAAF | 2021/10/16 18:00 | Case Western Reserve Spartans v Bethany Bison | W | 53-0 |
| NCAAF | 2021/10/02 17:00 | St Vincent Bearcats v Case Western Reserve Spartans | L | 42-40 |
| NCAAF | 2021/09/25 23:00 | Case Western Reserve Spartans v Washington And Jefferson Presidents | L | 14-37 |
| NCAAF | 2021/09/18 23:00 | Case Western Reserve Spartans v Westminster Titans | L | 12-34 |
| NCAAF | 2021/09/11 17:00 | Waynesburg Yellow Jackets v Case Western Reserve Spartans | W | 33-66 |