Stadium: John F. Wiley Stadium Round: 1
| NCAAF | 2019/11/09 18:30 | Waynesburg Yellow Jackets v Case Western Reserve Spartans | L | 24-27 |
| NCAAF | 2018/11/03 18:00 | Case Western Reserve Spartans v Waynesburg Yellow Jackets | L | 41-17 |
| NCAAF | 2021/09/04 20:00 | Muskingum Muskies v Waynesburg Yellow Jackets | L | 49-6 |
| NCAAF | 2019/11/16 18:00 | Washington And Jefferson Presidents v Waynesburg Yellow Jackets | L | 50-14 |
| NCAAF | 2019/11/09 18:30 | Waynesburg Yellow Jackets v Case Western Reserve Spartans | L | 24-27 |
| NCAAF | 2019/10/26 17:30 | Waynesburg Yellow Jackets v St Vincent Bearcats | L | 17-21 |
| NCAAF | 2019/10/19 17:30 | Waynesburg Yellow Jackets v Grove City Wolverines | L | 24-42 |
| NCAAF | 2019/10/12 23:00 | Carnegie Mellon Tartans v Waynesburg Yellow Jackets | L | 24-3 |
| NCAAF | 2019/10/05 17:30 | Waynesburg Yellow Jackets v Thiel Tomcats | W | 14-13 |
| NCAAF | 2019/09/28 19:00 | Geneva Golden Tornadoes v Waynesburg Yellow Jackets | L | 27-7 |
| NCAAF | 2021/09/04 23:00 | Rochester Yellowjackets v Case Western Reserve Spartans | W | 20-27 |
| NCAAF | 2019/11/23 17:00 | Union Dutchmen v Case Western Reserve Spartans | L | 24-21 |
| NCAAF | 2019/11/16 18:00 | Carnegie Mellon Tartans v Case Western Reserve Spartans | L | 24-21 |
| NCAAF | 2019/11/09 18:30 | Waynesburg Yellow Jackets v Case Western Reserve Spartans | W | 24-27 |
| NCAAF | 2019/11/02 18:00 | Case Western Reserve Spartans v Bethany Bison | W | 35-14 |
| NCAAF | 2019/10/26 18:00 | Case Western Reserve Spartans v Geneva Golden Tornadoes | W | 30-23 |
| NCAAF | 2019/10/19 17:00 | St Vincent Bearcats v Case Western Reserve Spartans | W | 26-34 |
| NCAAF | 2019/10/12 17:30 | Case Western Reserve Spartans v Washington And Jefferson Presidents | W | 35-19 |