Stadium: DiSanto Field Round: 1
| NCAAF | 2019/09/21 23:00 | Case Western Reserve Spartans v Grove City Wolverines | W | 52-14 |
| NCAAF | 2018/09/15 23:00 | Grove City Wolverines v Case Western Reserve Spartans | W | 23-49 |
| NCAAF | 2021/10/30 17:00 | Thiel Tomcats v Case Western Reserve Spartans | W | 12-30 |
| NCAAF | 2021/10/23 17:30 | Case Western Reserve Spartans v Geneva Golden Tornadoes | W | 42-38 |
| NCAAF | 2021/10/16 18:00 | Case Western Reserve Spartans v Bethany Bison | W | 53-0 |
| NCAAF | 2021/10/02 17:00 | St Vincent Bearcats v Case Western Reserve Spartans | L | 42-40 |
| NCAAF | 2021/09/25 23:00 | Case Western Reserve Spartans v Washington And Jefferson Presidents | L | 14-37 |
| NCAAF | 2021/09/18 23:00 | Case Western Reserve Spartans v Westminster Titans | L | 12-34 |
| NCAAF | 2021/09/11 17:00 | Waynesburg Yellow Jackets v Case Western Reserve Spartans | W | 33-66 |
| NCAAF | 2021/09/04 23:00 | Rochester Yellowjackets v Case Western Reserve Spartans | W | 20-27 |
| NCAAF | 2021/10/30 17:00 | Grove City Wolverines v Washington And Jefferson Presidents | L | 24-28 |
| NCAAF | 2021/10/16 17:00 | St Vincent Bearcats v Grove City Wolverines | W | 29-41 |
| NCAAF | 2021/10/09 18:00 | Grove City Wolverines v Geneva Golden Tornadoes | W | 56-7 |
| NCAAF | 2021/10/02 17:00 | Waynesburg Yellow Jackets v Grove City Wolverines | W | 0-38 |
| NCAAF | 2021/09/25 17:00 | Westminster Titans v Grove City Wolverines | L | 33-32 |
| NCAAF | 2021/09/18 17:00 | Grove City Wolverines v Carnegie Mellon Tartans | W | 13-6 |
| NCAAF | 2021/09/11 23:00 | Grove City Wolverines v Bethany Bison | W | 48-15 |
| NCAAF | 2021/09/04 17:00 | Juniata Eagles v Grove City Wolverines | W | 14-39 |