Stadium: Justin F. Coressel Stadium Round: 1
| NCAAF | 2019/10/26 17:30 | Franklin College Grizzlies v Defiance Yellow Jackets | L | 28-0 |
| NCAAF | 2018/10/06 17:30 | Defiance Yellow Jackets v Franklin College Grizzlies | L | 28-55 |
| NCAAF | 2021/10/23 17:30 | Defiance Yellow Jackets v Mount St. Joseph Lions | W | 14-13 |
| NCAAF | 2021/10/16 17:30 | Hanover v Defiance Yellow Jackets | L | 51-0 |
| NCAAF | 2021/10/09 17:30 | Manchester Spartans v Defiance Yellow Jackets | L | 22-0 |
| NCAAF | 2021/10/02 17:30 | Defiance Yellow Jackets v Rose Hulman Engineers | L | 14-63 |
| NCAAF | 2021/09/25 16:00 | Defiance Yellow Jackets v Alfred State Pioneers | L | 28-35 |
| NCAAF | 2021/09/11 17:30 | Defiance Yellow Jackets v Albion Britons | L | 0-51 |
| NCAAF | 2021/09/02 22:00 | Capital Crusaders v Defiance Yellow Jackets | L | 41-7 |
| NCAAF | 2019/11/16 18:30 | Defiance Yellow Jackets v Bluffton Beavers | W | 10-7 |
| NCAAF | 2021/10/23 17:30 | Anderson Ravens v Franklin College Grizzlies | W | 0-17 |
| NCAAF | 2021/10/16 17:30 | Franklin College Grizzlies v Bluffton Beavers | W | 45-6 |
| NCAAF | 2021/10/09 17:30 | Mount St. Joseph Lions v Franklin College Grizzlies | L | 28-14 |
| NCAAF | 2021/10/02 17:30 | Franklin College Grizzlies v Manchester Spartans | L | 24-27 |
| NCAAF | 2021/09/18 17:30 | Franklin College Grizzlies v Uw-Platteville Pioneers | L | 19-44 |
| NCAAF | 2021/09/11 17:30 | Franklin College Grizzlies v Rhodes Lynx | W | 36-29 |
| NCAAF | 2021/09/04 18:30 | Illinois Wesleyan Titans v Franklin College Grizzlies | W | 21-35 |
| NCAAF | 2019/11/16 18:30 | Hanover v Franklin College Grizzlies | L | 27-21 |