Stadium: Pete FioRito Stadium at McKinzie Field Round: 1
| NCAAF | 2021/10/30 18:00 | Eureka Red Devils v Lakeland Muskies | L | 16-45 |
| NCAAF | 2021/10/23 23:00 | Wisconsin Lutheran Warriors v Eureka Red Devils | L | 68-41 |
| NCAAF | 2021/10/16 23:00 | Aurora Spartans v Eureka Red Devils | L | 49-7 |
| NCAAF | 2021/10/09 18:00 | Eureka Red Devils v Concordia Wisconsin Falcons | L | 32-41 |
| NCAAF | 2021/10/02 21:00 | Eureka Red Devils v Concordia Chicago Cougars | W | 38-13 |
| NCAAF | 2021/09/25 18:00 | Benedictine Eagles v Eureka Red Devils | L | 49-29 |
| NCAAF | 2021/09/18 18:00 | Rockford Regents v Eureka Red Devils | W | 57-58 |
| NCAAF | 2021/09/11 18:00 | Eureka Red Devils v Olivet Comets | L | 23-42 |
| NCAAF | 2021/10/30 18:00 | St Norbert Green Knights v Rockford Regents | W | 77-7 |
| NCAAF | 2021/10/23 20:00 | St Norbert Green Knights v Aurora Spartans | L | 7-25 |
| NCAAF | 2021/10/16 18:00 | Concordia Wisconsin Falcons v St Norbert Green Knights | L | 24-14 |
| NCAAF | 2021/10/09 17:00 | St Norbert Green Knights v Wisconsin Lutheran Warriors | W | 68-0 |
| NCAAF | 2021/10/02 18:00 | St Norbert Green Knights v Benedictine Eagles | L | 34-41 |
| NCAAF | 2021/09/25 23:00 | Lakeland Muskies v St Norbert Green Knights | L | 40-8 |
| NCAAF | 2021/09/11 18:00 | Uw-Stout Blue Devils v St Norbert Green Knights | L | 34-14 |
| NCAAF | 2021/09/04 18:00 | St Norbert Green Knights v Loras Duhawks | W | 21-14 |