Stadium: McCully Stadium Round: 1
| NCAAF | 2019/09/21 23:00 | Wheaton Thunder v Illinois Wesleyan Titans | W | 24-10 |
| NCAAF | 2018/09/15 23:00 | Illinois Wesleyan Titans v Wheaton Thunder | L | 24-14 |
| NCAAF | 2021/10/30 18:00 | Elmhurst Bluejays v Wheaton Thunder | W | 0-44 |
| NCAAF | 2021/10/23 23:00 | Wheaton Thunder v Carthage Red Men | W | 69-20 |
| NCAAF | 2021/10/16 18:00 | Carroll Pioneers v Wheaton Thunder | W | 13-48 |
| NCAAF | 2021/10/09 18:00 | Wheaton Thunder v Augustana Augie | W | 45-0 |
| NCAAF | 2021/10/02 23:00 | Washington Bears v Wheaton Thunder | W | 10-40 |
| NCAAF | 2021/09/25 18:00 | North Park Vikings v Wheaton Thunder | W | 27-58 |
| NCAAF | 2021/09/18 23:00 | Wheaton Thunder v North Central Illinois | L | 7-20 |
| NCAAF | 2021/09/04 18:00 | Wheaton Thunder v Northwestern Eagles | W | 56-0 |
| NCAAF | 2021/10/30 18:00 | Illinois Wesleyan Titans v North Park Vikings | W | 56-6 |
| NCAAF | 2021/10/23 23:00 | North Central Illinois v Illinois Wesleyan Titans | L | 55-7 |
| NCAAF | 2021/10/16 18:00 | Illinois Wesleyan Titans v Millikin Big Blue | W | 14-0 |
| NCAAF | 2021/10/09 18:00 | Washington Bears v Illinois Wesleyan Titans | L | 38-22 |
| NCAAF | 2021/10/02 18:00 | Illinois Wesleyan Titans v Elmhurst Bluejays | W | 52-3 |
| NCAAF | 2021/09/25 18:00 | Carthage Red Men v Illinois Wesleyan Titans | L | 62-35 |
| NCAAF | 2021/09/18 18:00 | Carroll Pioneers v Illinois Wesleyan Titans | L | 34-33 |
| NCAAF | 2021/09/04 18:30 | Illinois Wesleyan Titans v Franklin College Grizzlies | L | 21-35 |