Stadium: Justin F. Coressel Stadium Round: 1
| NCAAF | 2019/10/05 17:30 | Mount St. Joseph Lions v Defiance Yellow Jackets | L | 59-6 |
| NCAAF | 2018/10/20 17:30 | Defiance Yellow Jackets v Mount St. Joseph Lions | L | 0-20 |
| NCAAF | 2021/10/16 17:30 | Hanover v Defiance Yellow Jackets | L | 51-0 |
| NCAAF | 2021/10/09 17:30 | Manchester Spartans v Defiance Yellow Jackets | L | 22-0 |
| NCAAF | 2021/10/02 17:30 | Defiance Yellow Jackets v Rose Hulman Engineers | L | 14-63 |
| NCAAF | 2021/09/25 16:00 | Defiance Yellow Jackets v Alfred State Pioneers | L | 28-35 |
| NCAAF | 2021/09/11 17:30 | Defiance Yellow Jackets v Albion Britons | L | 0-51 |
| NCAAF | 2021/09/02 22:00 | Capital Crusaders v Defiance Yellow Jackets | L | 41-7 |
| NCAAF | 2019/11/16 18:30 | Defiance Yellow Jackets v Bluffton Beavers | W | 10-7 |
| NCAAF | 2019/11/09 18:30 | Defiance Yellow Jackets v Manchester Spartans | L | 0-19 |
| NCAAF | 2021/10/16 17:30 | Mount St. Joseph Lions v Manchester Spartans | W | 28-0 |
| NCAAF | 2021/10/09 17:30 | Mount St. Joseph Lions v Franklin College Grizzlies | W | 28-14 |
| NCAAF | 2021/10/02 17:30 | Bluffton Beavers v Mount St. Joseph Lions | W | 27-45 |
| NCAAF | 2021/09/18 17:00 | Trine Thunder v Mount St. Joseph Lions | L | 31-30 |
| NCAAF | 2021/09/11 16:00 | Mount St. Joseph Lions v Alfred Saxons | W | 33-14 |
| NCAAF | 2021/09/04 17:30 | Mount St. Joseph Lions v Albion Britons | L | 20-36 |
| NCAAF | 2019/11/16 18:00 | Suny Maritime Privateers v Mount St. Joseph Lions | L | 11-9 |
| NCAAF | 2019/11/09 18:30 | Anderson Ravens v Mount St. Joseph Lions | W | 46-76 |