Stadium: Alumni Stadium Round: 1
| NCAAF | 2019/10/26 17:30 | Hanover v Manchester Spartans | W | 56-7 |
| NCAAF | 2018/10/20 17:30 | Manchester Spartans v Hanover | W | 14-48 |
| NCAAF | 2021/10/23 17:30 | Bluffton Beavers v Hanover | W | 10-41 |
| NCAAF | 2021/10/16 17:30 | Hanover v Defiance Yellow Jackets | W | 51-0 |
| NCAAF | 2021/10/09 18:00 | Rose Hulman Engineers v Hanover | L | 31-21 |
| NCAAF | 2021/10/02 17:30 | Hanover v Anderson Ravens | W | 49-0 |
| NCAAF | 2021/09/18 17:00 | Albion Britons v Hanover | L | 24-14 |
| NCAAF | 2021/09/11 17:30 | Hanover v Adrian Bulldogs | W | 21-14 |
| NCAAF | 2021/09/04 23:00 | Centre Colonels v Hanover | L | 56-34 |
| NCAAF | 2019/11/23 17:00 | Mount Union v Hanover | L | 65-14 |
| NCAAF | 2021/10/23 17:30 | Manchester Spartans v Rose Hulman Engineers | L | 14-57 |
| NCAAF | 2021/10/16 17:30 | Mount St. Joseph Lions v Manchester Spartans | L | 28-0 |
| NCAAF | 2021/10/09 17:30 | Manchester Spartans v Defiance Yellow Jackets | W | 22-0 |
| NCAAF | 2021/10/02 17:30 | Franklin College Grizzlies v Manchester Spartans | W | 24-27 |
| NCAAF | 2021/09/18 17:00 | Olivet Comets v Manchester Spartans | L | 59-7 |
| NCAAF | 2021/09/11 22:00 | Manchester Spartans v Alma College Scots | L | 23-47 |
| NCAAF | 2021/09/02 23:00 | Manchester Spartans v Trine Thunder | L | 14-52 |
| NCAAF | 2019/11/16 18:30 | Manchester Spartans v Anderson Ravens | W | 70-54 |