Stadium: Cook Stadium Round: 1
| NCAAF | 2019/10/26 20:00 | Rose Hulman Engineers v Mount St. Joseph Lions | W | 29-8 |
| NCAAF | 2018/09/15 17:30 | Mount St. Joseph Lions v Rose Hulman Engineers | L | 54-35 |
| NCAAF | 2021/11/06 17:30 | Franklin College Grizzlies v Rose Hulman Engineers | W | 14-38 |
| NCAAF | 2021/10/30 17:30 | Rose Hulman Engineers v Bluffton Beavers | W | 48-12 |
| NCAAF | 2021/10/23 17:30 | Manchester Spartans v Rose Hulman Engineers | W | 14-57 |
| NCAAF | 2021/10/16 17:30 | Rose Hulman Engineers v Anderson Ravens | W | 62-7 |
| NCAAF | 2021/10/09 18:00 | Rose Hulman Engineers v Hanover | W | 31-21 |
| NCAAF | 2021/10/02 17:30 | Defiance Yellow Jackets v Rose Hulman Engineers | W | 14-63 |
| NCAAF | 2021/09/18 18:00 | Hope Flying Dutchmen v Rose Hulman Engineers | L | 27-20 |
| NCAAF | 2021/09/11 23:00 | Trine Thunder v Rose Hulman Engineers | W | 30-31 |
| NCAAF | 2021/11/06 17:30 | Mount St. Joseph Lions v Hanover | W | 23-6 |
| NCAAF | 2021/10/30 17:30 | Mount St. Joseph Lions v Anderson Ravens | W | 35-18 |
| NCAAF | 2021/10/23 17:30 | Defiance Yellow Jackets v Mount St. Joseph Lions | L | 14-13 |
| NCAAF | 2021/10/16 17:30 | Mount St. Joseph Lions v Manchester Spartans | W | 28-0 |
| NCAAF | 2021/10/09 17:30 | Mount St. Joseph Lions v Franklin College Grizzlies | W | 28-14 |
| NCAAF | 2021/10/02 17:30 | Bluffton Beavers v Mount St. Joseph Lions | W | 27-45 |
| NCAAF | 2021/09/18 17:00 | Trine Thunder v Mount St. Joseph Lions | L | 31-30 |
| NCAAF | 2021/09/11 16:00 | Mount St. Joseph Lions v Alfred Saxons | W | 33-14 |