Stadium: Blackstock Stadium Round: 1
| NCAAF | 2019/11/02 22:00 | Denison Big Red v Depauw Tigers | L | 42-7 |
| NCAAF | 2018/10/13 17:00 | Depauw Tigers v Denison Big Red | L | 12-20 |
| NCAAF | 2021/10/23 17:00 | Allegheny Gators v Depauw Tigers | W | 14-38 |
| NCAAF | 2021/10/16 17:00 | Depauw Tigers v Ohio Wesleyan Battling Bishops | W | 24-7 |
| NCAAF | 2021/10/09 18:00 | Wittenberg Tigers v Depauw Tigers | W | 14-17 |
| NCAAF | 2021/10/02 17:00 | Depauw Tigers v Hiram Terriers | W | 57-7 |
| NCAAF | 2021/09/25 18:00 | Wooster Scots v Depauw Tigers | W | 30-34 |
| NCAAF | 2021/09/18 17:00 | Depauw Tigers v Kenyon Lords | W | 44-0 |
| NCAAF | 2021/09/11 22:00 | Butler v Depauw Tigers | L | 49-24 |
| NCAAF | 2019/11/16 18:00 | Depauw Tigers v Wabash Little Giants | W | 17-13 |
| NCAAF | 2021/10/23 19:00 | Denison Big Red v Wooster Scots | W | 52-28 |
| NCAAF | 2021/10/16 17:00 | Kenyon Lords v Denison Big Red | W | 7-45 |
| NCAAF | 2021/10/02 19:00 | Denison Big Red v Wabash Little Giants | L | 38-39 |
| NCAAF | 2021/09/25 23:00 | Denison Big Red v Wittenberg Tigers | W | 21-16 |
| NCAAF | 2021/09/18 17:00 | Oberlin Yeomen v Denison Big Red | W | 12-59 |
| NCAAF | 2021/09/11 19:00 | Denison Big Red v Allegheny Gators | W | 31-0 |
| NCAAF | 2021/09/04 22:00 | Ohio Northern Polar Bears v Denison Big Red | L | 34-10 |
| NCAAF | 2019/11/16 18:00 | Denison Big Red v Kenyon Lords | W | 52-13 |