Stadium: Blackstock Stadium Round: 1
| NCAAF | 2019/11/09 18:00 | Depauw Tigers v Oberlin Yeomen | W | 34-0 |
| NCAAF | 2018/10/06 17:00 | Oberlin Yeomen v Depauw Tigers | W | 26-28 |
| NCAAF | 2021/10/30 17:00 | Depauw Tigers v Denison Big Red | W | 27-10 |
| NCAAF | 2021/10/23 17:00 | Allegheny Gators v Depauw Tigers | W | 14-38 |
| NCAAF | 2021/10/16 17:00 | Depauw Tigers v Ohio Wesleyan Battling Bishops | W | 24-7 |
| NCAAF | 2021/10/09 18:00 | Wittenberg Tigers v Depauw Tigers | W | 14-17 |
| NCAAF | 2021/10/02 17:00 | Depauw Tigers v Hiram Terriers | W | 57-7 |
| NCAAF | 2021/09/25 18:00 | Wooster Scots v Depauw Tigers | W | 30-34 |
| NCAAF | 2021/09/18 17:00 | Depauw Tigers v Kenyon Lords | W | 44-0 |
| NCAAF | 2021/09/11 22:00 | Butler v Depauw Tigers | L | 49-24 |
| NCAAF | 2021/10/23 17:00 | Hiram Terriers v Oberlin Yeomen | W | 28-31 |
| NCAAF | 2021/10/16 19:00 | Oberlin Yeomen v Wittenberg Tigers | L | 27-44 |
| NCAAF | 2021/10/09 18:00 | Wabash Little Giants v Oberlin Yeomen | L | 49-20 |
| NCAAF | 2021/10/02 17:00 | Oberlin Yeomen v Wooster Scots | L | 24-28 |
| NCAAF | 2021/09/25 16:00 | Kenyon Lords v Oberlin Yeomen | L | 24-21 |
| NCAAF | 2021/09/18 17:00 | Oberlin Yeomen v Denison Big Red | L | 12-59 |
| NCAAF | 2021/09/11 23:00 | Oberlin Yeomen v Ohio Wesleyan Battling Bishops | L | 6-62 |
| NCAAF | 2021/09/04 17:00 | Oberlin Yeomen v Kalamazoo Hornets | L | 17-24 |