Stadium: Blackstock Stadium Round: 1
| NCAAF | 2019/10/19 18:00 | Ohio Wesleyan Battling Bishops v Depauw Tigers | L | 28-13 |
| NCAAF | 2018/09/29 17:00 | Depauw Tigers v Ohio Wesleyan Battling Bishops | W | 38-17 |
| NCAAF | 2021/10/09 18:00 | Wittenberg Tigers v Depauw Tigers | W | 14-17 |
| NCAAF | 2021/10/02 17:00 | Depauw Tigers v Hiram Terriers | W | 57-7 |
| NCAAF | 2021/09/25 18:00 | Wooster Scots v Depauw Tigers | W | 30-34 |
| NCAAF | 2021/09/18 17:00 | Depauw Tigers v Kenyon Lords | W | 44-0 |
| NCAAF | 2021/09/11 22:00 | Butler v Depauw Tigers | L | 49-24 |
| NCAAF | 2019/11/16 18:00 | Depauw Tigers v Wabash Little Giants | W | 17-13 |
| NCAAF | 2019/11/09 18:00 | Depauw Tigers v Oberlin Yeomen | W | 34-0 |
| NCAAF | 2019/11/02 22:00 | Denison Big Red v Depauw Tigers | L | 42-7 |
| NCAAF | 2021/10/09 17:00 | Ohio Wesleyan Battling Bishops v Hiram Terriers | W | 34-17 |
| NCAAF | 2021/10/02 18:00 | Ohio Wesleyan Battling Bishops v Wittenberg Tigers | L | 23-24 |
| NCAAF | 2021/09/25 18:00 | Allegheny Gators v Ohio Wesleyan Battling Bishops | W | 19-28 |
| NCAAF | 2021/09/18 17:00 | Ohio Wesleyan Battling Bishops v Wooster Scots | W | 31-7 |
| NCAAF | 2021/09/11 23:00 | Oberlin Yeomen v Ohio Wesleyan Battling Bishops | W | 6-62 |
| NCAAF | 2021/09/04 16:00 | Otterbein Cardinals v Ohio Wesleyan Battling Bishops | W | 28-32 |
| NCAAF | 2019/11/16 18:00 | Wittenberg Tigers v Ohio Wesleyan Battling Bishops | L | 38-20 |
| NCAAF | 2019/11/09 18:00 | Ohio Wesleyan Battling Bishops v Denison Big Red | W | 19-10 |