Stadium: Hollett Little Giant Stadium Round: 1
| NCAAF | 2019/11/16 18:00 | Depauw Tigers v Wabash Little Giants | L | 17-13 |
| NCAAF | 2018/11/10 18:07 | Wabash Little Giants v Depauw Tigers | W | 24-17 |
| NCAAF | 2021/11/06 17:00 | Wabash Little Giants v Wittenberg Tigers | L | 14-35 |
| NCAAF | 2021/10/30 17:00 | Kenyon Lords v Wabash Little Giants | W | 34-59 |
| NCAAF | 2021/10/23 17:00 | Ohio Wesleyan Battling Bishops v Wabash Little Giants | L | 35-28 |
| NCAAF | 2021/10/16 17:00 | Wabash Little Giants v Wooster Scots | L | 41-44 |
| NCAAF | 2021/10/09 18:00 | Wabash Little Giants v Oberlin Yeomen | W | 49-20 |
| NCAAF | 2021/10/02 19:00 | Denison Big Red v Wabash Little Giants | W | 38-39 |
| NCAAF | 2021/09/18 18:00 | Wabash Little Giants v Allegheny Gators | W | 36-28 |
| NCAAF | 2021/09/11 16:00 | Hiram Terriers v Wabash Little Giants | W | 14-42 |
| NCAAF | 2021/11/06 17:00 | Depauw Tigers v Oberlin Yeomen | W | 66-13 |
| NCAAF | 2021/10/30 17:00 | Depauw Tigers v Denison Big Red | W | 27-10 |
| NCAAF | 2021/10/23 17:00 | Allegheny Gators v Depauw Tigers | W | 14-38 |
| NCAAF | 2021/10/16 17:00 | Depauw Tigers v Ohio Wesleyan Battling Bishops | W | 24-7 |
| NCAAF | 2021/10/09 18:00 | Wittenberg Tigers v Depauw Tigers | W | 14-17 |
| NCAAF | 2021/10/02 17:00 | Depauw Tigers v Hiram Terriers | W | 57-7 |
| NCAAF | 2021/09/25 18:00 | Wooster Scots v Depauw Tigers | W | 30-34 |
| NCAAF | 2021/09/18 17:00 | Depauw Tigers v Kenyon Lords | W | 44-0 |