Stadium: Rosenbloom Field Round: 1
| NCAAF | 2021/11/06 18:00 | Illinois College Blueboys v Grinnell Pioneers | L | 55-24 |
| NCAAF | 2021/10/30 18:00 | Grinnell Pioneers v Chicago Maroons | L | 3-78 |
| NCAAF | 2021/10/23 18:00 | Lake Forest Foresters v Grinnell Pioneers | L | 79-0 |
| NCAAF | 2021/10/16 18:00 | Grinnell Pioneers v Knox Prairie Fire | L | 28-49 |
| NCAAF | 2021/10/09 18:00 | Grinnell Pioneers v Ripon Red Hawks | L | 8-52 |
| NCAAF | 2021/10/02 18:00 | Beloit Buccaneers v Grinnell Pioneers | W | 13-40 |
| NCAAF | 2021/09/18 18:00 | Grinnell Pioneers v Lawrence Vikings | W | 35-28 |
| NCAAF | 2021/09/11 19:00 | Monmouth Scots v Grinnell Pioneers | L | 42-7 |
| NCAAF | 2021/11/06 18:00 | Knox Prairie Fire v Cornell Rams | W | 34-35 |
| NCAAF | 2021/10/30 18:00 | Cornell Rams v Illinois College Blueboys | L | 7-39 |
| NCAAF | 2021/10/23 19:00 | Monmouth Scots v Cornell Rams | L | 47-14 |
| NCAAF | 2021/10/16 18:00 | Cornell Rams v Chicago Maroons | L | 21-47 |
| NCAAF | 2021/10/09 19:00 | Cornell Rams v Lawrence Vikings | W | 35-24 |
| NCAAF | 2021/09/18 18:00 | Ripon Red Hawks v Cornell Rams | L | 31-13 |
| NCAAF | 2021/09/11 18:00 | Cornell Rams v Beloit Buccaneers | W | 38-7 |
| NCAAF | 2021/09/04 18:00 | Cornell Rams v Coe Kohawks | L | 7-38 |