Stadium: J. Henry “Hank” Cameron Stadium Round: 1
| NCAAF | 2021/10/30 16:00 | Nichols Bison v Husson Eagles | W | 12-14 |
| NCAAF | 2021/10/23 17:00 | University of New England Noreasters v Husson Eagles | W | 14-41 |
| NCAAF | 2021/10/16 17:00 | Husson Eagles v Endicott Gulls | L | 17-24 |
| NCAAF | 2021/10/09 17:00 | Husson Eagles v Curry Colonels | W | 21-14 |
| NCAAF | 2021/09/25 17:00 | Husson Eagles v Springfield Pride | W | 26-21 |
| NCAAF | 2021/09/17 22:00 | Husson Eagles v Dean Bulldogs | W | 42-14 |
| NCAAF | 2021/09/11 17:00 | Plymouth State Panthers v Husson Eagles | W | 7-10 |
| NCAAF | 2021/09/04 17:00 | Husson Eagles v Umass Dartmouth Corsairs | L | 14-21 |
| NCAAF | 2021/10/30 16:00 | Salve Regina Seahawks v Curry Colonels | W | 47-14 |
| NCAAF | 2021/10/23 16:00 | Salve Regina Seahawks v Endicott Gulls | W | 21-14 |
| NCAAF | 2021/10/16 16:00 | Nichols Bison v Salve Regina Seahawks | W | 20-35 |
| NCAAF | 2021/10/09 17:00 | Salve Regina Seahawks v University of New England Noreasters | W | 48-6 |
| NCAAF | 2021/10/02 17:00 | Western New England Golden Bears v Salve Regina Seahawks | L | 41-3 |
| NCAAF | 2021/09/25 16:00 | Salve Regina Seahawks v Rowan Profs | W | 50-35 |
| NCAAF | 2021/09/18 18:00 | Montclair State Red Hawks v Salve Regina Seahawks | W | 21-24 |
| NCAAF | 2021/09/11 17:00 | Salve Regina Seahawks v Mit Engineers | W | 21-16 |