Stadium: John F. Wiley Stadium Round: 1
| NCAAF | 2019/09/21 17:30 | Waynesburg Yellow Jackets v Bethany Bison | L | 17-41 |
| NCAAF | 2018/09/15 23:00 | Bethany Bison v Waynesburg Yellow Jackets | L | 22-13 |
| NCAAF | 2021/10/30 23:00 | Geneva Golden Tornadoes v Waynesburg Yellow Jackets | L | 49-3 |
| NCAAF | 2021/10/23 17:00 | Waynesburg Yellow Jackets v St Vincent Bearcats | L | 7-38 |
| NCAAF | 2021/10/16 17:00 | Westminster Titans v Waynesburg Yellow Jackets | L | 66-14 |
| NCAAF | 2021/10/02 17:00 | Waynesburg Yellow Jackets v Grove City Wolverines | L | 0-38 |
| NCAAF | 2021/09/25 23:00 | Carnegie Mellon Tartans v Waynesburg Yellow Jackets | L | 39-3 |
| NCAAF | 2021/09/18 17:00 | Waynesburg Yellow Jackets v Thiel Tomcats | W | 52-14 |
| NCAAF | 2021/09/11 17:00 | Waynesburg Yellow Jackets v Case Western Reserve Spartans | L | 33-66 |
| NCAAF | 2021/09/04 20:00 | Muskingum Muskies v Waynesburg Yellow Jackets | L | 49-6 |
| NCAAF | 2021/10/30 17:00 | Bethany Bison v Westminster Titans | L | 6-42 |
| NCAAF | 2021/10/16 18:00 | Case Western Reserve Spartans v Bethany Bison | L | 53-0 |
| NCAAF | 2021/10/09 20:30 | Bethany Bison v Thiel Tomcats | W | 28-7 |
| NCAAF | 2021/10/02 17:00 | Bethany Bison v Carnegie Mellon Tartans | L | 7-47 |
| NCAAF | 2021/09/25 23:00 | Bethany Bison v Geneva Golden Tornadoes | L | 7-42 |
| NCAAF | 2021/09/18 22:00 | Washington And Jefferson Presidents v Bethany Bison | L | 28-3 |
| NCAAF | 2021/09/11 23:00 | Grove City Wolverines v Bethany Bison | L | 48-15 |
| NCAAF | 2021/09/03 23:00 | Hiram Terriers v Bethany Bison | L | 41-21 |