Stadium: Person Field and Shangraw Stadium, Lycoming College Round: 1
| NCAAF | 2019/09/21 17:00 | Lycoming Warriors v Wilkes Colonels | L | 17-24 |
| NCAAF | 2018/10/27 17:00 | Wilkes Colonels v Lycoming Warriors | L | 14-7 |
| NCAAF | 2021/10/23 17:00 | Lycoming Warriors v Albright Lions | W | 28-7 |
| NCAAF | 2021/10/09 17:00 | Lycoming Warriors v Misericordia Cougars | W | 44-16 |
| NCAAF | 2021/10/02 17:00 | Lycoming Warriors v Delaware Valley Aggies | L | 7-32 |
| NCAAF | 2021/09/25 16:00 | Stevenson Mustangs v Lycoming Warriors | W | 28-29 |
| NCAAF | 2021/09/18 17:00 | Kings Monarchs v Lycoming Warriors | W | 8-28 |
| NCAAF | 2021/09/11 17:00 | Lycoming Warriors v Lebanon Valley Flying Dutchmen | W | 31-6 |
| NCAAF | 2021/09/04 17:00 | Susquehanna Crusaders v Lycoming Warriors | L | 44-10 |
| NCAAF | 2019/11/16 17:00 | Stevenson Mustangs v Lycoming Warriors | L | 31-0 |
| NCAAF | 2021/10/23 17:00 | Wilkes Colonels v Lebanon Valley Flying Dutchmen | W | 30-20 |
| NCAAF | 2021/10/16 17:00 | Widener Pride v Wilkes Colonels | L | 30-13 |
| NCAAF | 2021/10/09 16:00 | Albright Lions v Wilkes Colonels | W | 28-31 |
| NCAAF | 2021/10/02 16:00 | Wilkes Colonels v Stevenson Mustangs | W | 21-14 |
| NCAAF | 2021/09/25 17:00 | Wilkes Colonels v Alvernia Golden Wolves | W | 23-0 |
| NCAAF | 2021/09/18 17:00 | Misericordia Cougars v Wilkes Colonels | W | 15-35 |
| NCAAF | 2021/09/04 17:00 | Wilkes Colonels v Keystone Giants | W | 46-7 |
| NCAAF | 2019/11/16 17:00 | Kings Monarchs v Wilkes Colonels | W | 14-24 |