Stadium: Rocky Mount Sports Complex Round: 1
| NCAAF | 2021/10/30 18:00 | Huntingdon Hawks v Nc Wesleyan Battling Bishops | L | 30-7 |
| NCAAF | 2021/10/16 16:00 | Nc Wesleyan Battling Bishops v Maryville Scots | L | 26-31 |
| NCAAF | 2021/10/09 16:00 | Nc Wesleyan Battling Bishops v Greensboro Pride | W | 21-0 |
| NCAAF | 2021/10/02 22:00 | Averett Cougars v Nc Wesleyan Battling Bishops | W | 9-17 |
| NCAAF | 2021/09/25 17:00 | Lagrange Panthers v Nc Wesleyan Battling Bishops | W | 21-26 |
| NCAAF | 2021/09/18 16:00 | Nc Wesleyan Battling Bishops v Brevard Tornados | L | 7-32 |
| NCAAF | 2021/09/11 16:00 | Nc Wesleyan Battling Bishops v Shenandoah Hornets | L | 21-30 |
| NCAAF | 2021/09/05 16:00 | Nc Wesleyan Battling Bishops v Emory And Henry Wasps | L | 7-36 |
| NCAAF | 2021/10/30 17:00 | Southern Virginia Knights v Averett Cougars | L | 23-28 |
| NCAAF | 2021/10/23 17:00 | Brevard Tornados v Southern Virginia Knights | L | 7-3 |
| NCAAF | 2021/10/16 17:00 | Southern Virginia Knights v Greensboro Pride | W | 31-14 |
| NCAAF | 2021/10/09 17:00 | Southern Virginia Knights v Huntingdon Hawks | L | 20-48 |
| NCAAF | 2021/10/02 17:00 | Maryville Scots v Southern Virginia Knights | L | 38-17 |
| NCAAF | 2021/09/25 17:00 | Methodist Monarchs v Southern Virginia Knights | L | 37-14 |
| NCAAF | 2021/09/18 17:00 | Southern Virginia Knights v Lagrange Panthers | L | 34-38 |
| NCAAF | 2021/09/11 17:00 | Southern Virginia Knights v Bridgewater Eagles | L | 17-35 |