Stadium: Hardee-McGee Field at Harris Stadium Round: 1
| NCAAF | 2019/10/12 18:00 | Centre Colonels v Sewanee Tigers | L | 24-21 |
| NCAAF | 2018/11/03 17:30 | Centre Colonels v Sewanee Tigers | L | 49-20 |
| NCAAF | 2021/10/30 18:00 | Millsaps Majors v Sewanee Tigers | L | 42-32 |
| NCAAF | 2021/10/23 17:00 | Sewanee Tigers v Trinity Tigers | L | 7-66 |
| NCAAF | 2021/10/16 19:00 | Berry Vikings v Sewanee Tigers | L | 59-0 |
| NCAAF | 2021/10/09 18:00 | Sewanee Tigers v Rhodes Lynx | L | 13-55 |
| NCAAF | 2021/10/02 23:00 | Birmingham Southern Panthers v Sewanee Tigers | L | 49-0 |
| NCAAF | 2021/09/18 18:00 | Sewanee Tigers v Westminster Blue Jays | L | 29-30 |
| NCAAF | 2021/09/11 18:00 | Washington And Lee Generals v Sewanee Tigers | L | 52-0 |
| NCAAF | 2019/11/16 19:00 | Hendrix Warriors v Sewanee Tigers | L | 47-17 |
| NCAAF | 2021/10/30 17:00 | Centre Colonels v Rhodes Lynx | W | 49-6 |
| NCAAF | 2021/10/23 17:00 | Millsaps Majors v Centre Colonels | W | 34-66 |
| NCAAF | 2021/10/16 17:00 | Centre Colonels v Birmingham Southern Panthers | L | 21-28 |
| NCAAF | 2021/10/09 18:30 | Trinity Tigers v Centre Colonels | L | 27-7 |
| NCAAF | 2021/10/02 17:00 | Centre Colonels v Hendrix Warriors | W | 42-21 |
| NCAAF | 2021/09/25 23:00 | Centre Colonels v Trine Thunder | W | 14-7 |
| NCAAF | 2021/09/11 17:00 | Maryville Scots v Centre Colonels | W | 21-40 |
| NCAAF | 2021/09/04 23:00 | Centre Colonels v Hanover | W | 56-34 |