Stadium: Deeds Field at Piper Stadium Round: 1
| NCAAF | 2019/11/09 18:00 | Ohio Wesleyan Battling Bishops v Denison Big Red | L | 19-10 |
| NCAAF | 2018/10/20 17:00 | Denison Big Red v Ohio Wesleyan Battling Bishops | W | 27-10 |
| NCAAF | 2021/11/06 17:00 | Hiram Terriers v Denison Big Red | W | 6-59 |
| NCAAF | 2021/10/30 17:00 | Depauw Tigers v Denison Big Red | L | 27-10 |
| NCAAF | 2021/10/23 19:00 | Denison Big Red v Wooster Scots | W | 52-28 |
| NCAAF | 2021/10/16 17:00 | Kenyon Lords v Denison Big Red | W | 7-45 |
| NCAAF | 2021/10/02 19:00 | Denison Big Red v Wabash Little Giants | L | 38-39 |
| NCAAF | 2021/09/25 23:00 | Denison Big Red v Wittenberg Tigers | W | 21-16 |
| NCAAF | 2021/09/18 17:00 | Oberlin Yeomen v Denison Big Red | W | 12-59 |
| NCAAF | 2021/09/11 19:00 | Denison Big Red v Allegheny Gators | W | 31-0 |
| NCAAF | 2021/11/06 17:00 | Ohio Wesleyan Battling Bishops v Kenyon Lords | W | 52-17 |
| NCAAF | 2021/10/23 17:00 | Ohio Wesleyan Battling Bishops v Wabash Little Giants | W | 35-28 |
| NCAAF | 2021/10/16 17:00 | Depauw Tigers v Ohio Wesleyan Battling Bishops | L | 24-7 |
| NCAAF | 2021/10/09 17:00 | Ohio Wesleyan Battling Bishops v Hiram Terriers | W | 34-17 |
| NCAAF | 2021/10/02 18:00 | Ohio Wesleyan Battling Bishops v Wittenberg Tigers | L | 23-24 |
| NCAAF | 2021/09/25 18:00 | Allegheny Gators v Ohio Wesleyan Battling Bishops | W | 19-28 |
| NCAAF | 2021/09/18 17:00 | Ohio Wesleyan Battling Bishops v Wooster Scots | W | 31-7 |
| NCAAF | 2021/09/11 23:00 | Oberlin Yeomen v Ohio Wesleyan Battling Bishops | W | 6-62 |