Stadium: Leckonby Stadium Round: 1
| NCAAF | 2019/10/26 17:00 | St Lawrence Saints v Rpi Engineers | W | 35-21 |
| NCAAF | 2018/11/03 16:00 | Rpi Engineers v St Lawrence Saints | L | 27-20 |
| NCAAF | 2021/10/30 17:00 | St Lawrence Saints v Rochester Yellowjackets | W | 34-10 |
| NCAAF | 2021/10/23 17:00 | Hobart Statesmen v St Lawrence Saints | L | 17-13 |
| NCAAF | 2021/10/16 17:00 | St Lawrence Saints v Ithaca Bombers | L | 0-17 |
| NCAAF | 2021/10/09 17:00 | Union Dutchmen v St Lawrence Saints | L | 37-7 |
| NCAAF | 2021/09/25 20:00 | St Lawrence Saints v Castleton Spartans | W | 55-3 |
| NCAAF | 2021/09/17 23:00 | Morrisville State Mustangs v St Lawrence Saints | W | 14-27 |
| NCAAF | 2021/09/11 17:00 | St Lawrence Saints v Norwich Cadets | W | 37-7 |
| NCAAF | 2021/09/04 16:00 | Endicott Gulls v St Lawrence Saints | L | 27-14 |
| NCAAF | 2021/10/30 16:00 | Rpi Engineers v Ithaca Bombers | W | 14-11 |
| NCAAF | 2021/10/16 17:00 | Hobart Statesmen v Rpi Engineers | L | 10-9 |
| NCAAF | 2021/10/09 16:00 | Rpi Engineers v Buffalo State Bengals | W | 24-16 |
| NCAAF | 2021/10/02 16:00 | Rpi Engineers v Rochester Yellowjackets | W | 38-22 |
| NCAAF | 2021/09/25 16:00 | Rpi Engineers v St John Fisher Cardinals | W | 41-7 |
| NCAAF | 2021/09/18 18:30 | Wpi Engineers v Rpi Engineers | W | 10-24 |
| NCAAF | 2021/09/11 16:00 | Rpi Engineers v Stevenson Mustangs | W | 14-10 |
| NCAAF | 2021/09/04 18:00 | Rpi Engineers v Montclair State Red Hawks | W | 21-20 |