[14] Southampton 1-0 Arsenal [5] 2022-04-16 14:00
Stadium: St. Mary's Stadium Round: 33
Referee: Peter Bankes Home Manager: Ralph Hasenhuttl Away Manager: Mikel Arteta
Head to Head
| England Premier League | 2021/12/11 15:00 | Arsenal v Southampton | L | 3-0 |
| England Premier League | 2021/01/26 20:15 | Southampton v Arsenal | L | 1-3 |
| England FA Cup | 2021/01/23 12:15 | Southampton v Arsenal | W | 1-0 |
| England Premier League | 2020/12/16 18:00 | Arsenal v Southampton | D | 1-1 |
| England Premier League | 2020/06/25 17:00 | Southampton v Arsenal | L | 0-2 |
| England Premier League | 2019/11/23 15:00 | Arsenal v Southampton | D | 2-2 |
| England Premier League | 2019/02/24 14:05 | Arsenal v Southampton | L | 2-0 |
| England Premier League | 2018/12/16 13:30 | Southampton v Arsenal | W | 3-2 |
Home History
| England Premier League | 2022/04/09 14:00 | Southampton v Chelsea | L | 0-6 |
| England Premier League | 2022/04/02 14:00 | Leeds v Southampton | D | 1-1 |
| England FA Cup | 2022/03/20 15:00 | Southampton v Man City | L | 1-4 |
| England Premier League | 2022/03/13 14:00 | Southampton v Watford | L | 1-2 |
| England Premier League | 2022/03/10 19:30 | Southampton v Newcastle | L | 1-2 |
| England Premier League | 2022/03/05 15:00 | Aston Villa v Southampton | L | 4-0 |
| England FA Cup | 2022/03/02 19:30 | Southampton v West Ham | W | 3-1 |
| England Premier League | 2022/02/25 20:00 | Southampton v Norwich | W | 2-0 |
Away History
| England Premier League | 2022/04/09 14:00 | Arsenal v Brighton | L | 1-2 |
| England Premier League | 2022/04/04 19:00 | Crystal Palace v Arsenal | L | 3-0 |
| England Premier League | 2022/03/19 12:30 | Aston Villa v Arsenal | W | 0-1 |
| England Premier League | 2022/03/16 20:15 | Arsenal v Liverpool | L | 0-2 |
| England Premier League | 2022/03/13 16:30 | Arsenal v Leicester | W | 2-0 |
| England Premier League | 2022/03/06 14:00 | Watford v Arsenal | W | 2-3 |
| England Premier League | 2022/02/24 19:45 | Arsenal v Wolverhampton | W | 2-1 |
| England Premier League | 2022/02/19 15:00 | Arsenal v Brentford | W | 2-1 |