Stadium: Edwin Fauver Stadium Round: 1
| NCAAF | 2019/09/07 23:00 | Rochester Yellowjackets v Case Western Reserve Spartans | L | 6-37 |
| NCAAF | 2018/09/01 23:00 | Case Western Reserve Spartans v Rochester Yellowjackets | L | 38-10 |
| NCAAF | 2019/11/16 17:00 | Rochester Yellowjackets v Hobart Statesmen | L | 20-51 |
| NCAAF | 2019/11/09 18:00 | St Lawrence Saints v Rochester Yellowjackets | L | 51-19 |
| NCAAF | 2019/10/26 16:00 | Rochester Yellowjackets v Ithaca Bombers | L | 0-59 |
| NCAAF | 2019/10/19 16:00 | Buffalo State Bengals v Rochester Yellowjackets | L | 13-7 |
| NCAAF | 2019/10/12 16:00 | Rochester Yellowjackets v Union Dutchmen | L | 19-47 |
| NCAAF | 2019/10/05 16:05 | Rpi Engineers v Rochester Yellowjackets | L | 38-0 |
| NCAAF | 2019/09/28 22:00 | Alfred Saxons v Rochester Yellowjackets | L | 56-13 |
| NCAAF | 2019/09/21 16:00 | Rochester Yellowjackets v Alfred State Pioneers | L | 21-27 |
| NCAAF | 2019/11/23 17:00 | Union Dutchmen v Case Western Reserve Spartans | L | 24-21 |
| NCAAF | 2019/11/16 18:00 | Carnegie Mellon Tartans v Case Western Reserve Spartans | L | 24-21 |
| NCAAF | 2019/11/09 18:30 | Waynesburg Yellow Jackets v Case Western Reserve Spartans | W | 24-27 |
| NCAAF | 2019/11/02 18:00 | Case Western Reserve Spartans v Bethany Bison | W | 35-14 |
| NCAAF | 2019/10/26 18:00 | Case Western Reserve Spartans v Geneva Golden Tornadoes | W | 30-23 |
| NCAAF | 2019/10/19 17:00 | St Vincent Bearcats v Case Western Reserve Spartans | W | 26-34 |
| NCAAF | 2019/10/12 17:30 | Case Western Reserve Spartans v Washington And Jefferson Presidents | W | 35-19 |
| NCAAF | 2019/10/05 23:00 | Case Western Reserve Spartans v Westminster Titans | W | 21-13 |