Stadium: Dave Wolk Stadium Round: 1
| NCAAF | 2021/10/09 16:00 | Dean Bulldogs v Castleton Spartans | W | 13-21 |
| NCAAF | 2021/10/02 16:00 | Suny Maritime Privateers v Castleton Spartans | L | 19-16 |
| NCAAF | 2021/09/25 20:00 | St Lawrence Saints v Castleton Spartans | L | 55-3 |
| NCAAF | 2021/09/18 19:00 | Castleton Spartans v Norwich Cadets | L | 12-28 |
| NCAAF | 2021/09/11 19:00 | Fitchburg State Falcons v Castleton Spartans | W | 0-35 |
| NCAAF | 2021/09/04 17:00 | Castleton Spartans v Plymouth State Panthers | W | 13-0 |
| NCAAF | 2019/11/09 17:00 | Dean Bulldogs v Castleton Spartans | W | 20-38 |
| NCAAF | 2019/11/02 18:00 | Castleton Spartans v Anna Maria Amcats | W | 33-19 |
| NCAAF | 2021/10/16 16:00 | Keystone Giants v Dean Bulldogs | L | 36-39 |
| NCAAF | 2021/10/09 16:00 | Gallaudet Bison v Keystone Giants | L | 34-14 |
| NCAAF | 2021/10/02 16:00 | Keystone Giants v Anna Maria Amcats | L | 35-55 |
| NCAAF | 2021/09/25 22:00 | Hobart Statesmen v Keystone Giants | L | 58-14 |
| NCAAF | 2021/09/18 17:00 | Keystone Giants v William Paterson Pioneers | L | 14-42 |
| NCAAF | 2021/09/11 16:00 | Keystone Giants v Misericordia Cougars | L | 7-28 |
| NCAAF | 2021/09/04 17:00 | Wilkes Colonels v Keystone Giants | L | 46-7 |