[3] Northampton 23-21 London Irish [10] 2021-10-02 13:00
Stadium: Franklin's Gardens Round: 3
Referee: Tom Foley
Head to Head
| Premiership Rugby | 2021/04/16 18:45 | Northampton v London Irish | W | 44-26 |
| Premiership Rugby | 2020/08/22 13:00 | London Irish v Northampton | W | 3-27 |
| Premiership Rugby | 2020/01/24 19:45 | Northampton v London Irish | L | 16-20 |
| Premiership Rugby | 2018/02/17 15:00 | Northampton v London Irish | W | 25-17 |
| Premiership Rugby | 2017/09/24 14:00 | London Irish v Northampton | W | 25-40 |
| Premiership Rugby | 2016/02/13 15:00 | Northampton v London Irish | W | 35-7 |
| Premiership Rugby | 2015/12/26 14:30 | London Irish v Northampton | L | 25-23 |
| Premiership Rugby | 2015/02/13 19:45 | Northampton v London Irish | W | 15-9 |
Home History
| Premiership Rugby | 2021/09/25 14:00 | Exeter Chiefs v Northampton | W | 24-26 |
| Premiership Rugby | 2021/09/18 14:00 | Northampton v Gloucester | W | 34-20 |
| Premiership Rugby | 2021/06/12 14:00 | Bath v Northampton | L | 30-24 |
| Premiership Rugby | 2021/06/06 14:00 | Northampton v Exeter Chiefs | L | 26-29 |
| Premiership Rugby | 2021/05/29 15:30 | Northampton v Wasps | W | 30-25 |
| Premiership Rugby | 2021/05/17 18:30 | Newcastle Falcons v Northampton | L | 18-10 |
| Premiership Rugby | 2021/05/08 13:00 | Northampton v Gloucester | L | 7-31 |
| Premiership Rugby | 2021/04/24 14:00 | Leicester v Northampton | W | 18-23 |
Away History
| Premiership Rugby | 2021/09/26 14:00 | London Irish v Sale Sharks | D | 31-31 |
| Premiership Rugby | 2021/09/18 14:00 | Worcester Warriors v London Irish | L | 36-24 |
| Premiership Rugby | 2021/06/05 15:30 | London Irish v Wasps | L | 36-39 |
| Premiership Rugby | 2021/05/28 18:45 | Gloucester v London Irish | L | 30-28 |
| Premiership Rugby | 2021/05/18 18:45 | London Irish v Exeter Chiefs | L | 12-31 |
| Premiership Rugby | 2021/05/08 14:00 | Newcastle Falcons v London Irish | L | 52-27 |
| Premiership Rugby | 2021/04/24 11:30 | London Irish v Harlequins | L | 21-25 |
| Premiership Rugby | 2021/04/16 18:45 | Northampton v London Irish | L | 44-26 |