[5] Exeter Chiefs 21-33 London Irish [10] 2021-10-23 14:00
Stadium: Sandy Park Round: 6
Referee: Hamish Smales
Head to Head
| Premiership Rugby | 2021/05/18 18:45 | London Irish v Exeter Chiefs | W | 12-31 |
| Premiership Rugby | 2021/02/13 16:15 | Exeter Chiefs v London Irish | W | 26-3 |
| Premiership Rugby | 2020/09/30 16:30 | Exeter Chiefs v London Irish | L | 19-22 |
| Premiership Rugby | 2020/01/05 14:30 | London Irish v Exeter Chiefs | W | 28-45 |
| Premiership Rugby | 2018/04/15 14:00 | London Irish v Exeter Chiefs | W | 5-45 |
| Premiership Rugby | 2017/09/09 14:00 | Exeter Chiefs v London Irish | W | 37-7 |
| Premiership Rugby | 2016/02/21 15:00 | London Irish v Exeter Chiefs | W | 15-22 |
| Premiership Rugby | 2015/10/24 17:00 | Exeter Chiefs v London Irish | W | 38-11 |
Home History
| Premiership Rugby | 2021/10/16 14:00 | Wasps v Exeter Chiefs | W | 23-27 |
| Premiership Rugby | 2021/10/09 14:00 | Exeter Chiefs v Worcester Warriors | W | 42-5 |
| Premiership Rugby | 2021/10/03 14:00 | Sale Sharks v Exeter Chiefs | W | 15-25 |
| Premiership Rugby | 2021/09/25 14:00 | Exeter Chiefs v Northampton | L | 24-26 |
| Premiership Rugby | 2021/09/18 14:00 | Leicester v Exeter Chiefs | L | 34-19 |
| Premiership Rugby | 2021/06/26 16:30 | Exeter Chiefs v Harlequins | L | 38-40 |
| Premiership Rugby | 2021/06/19 15:30 | Exeter Chiefs v Sale Sharks | W | 40-30 |
| Premiership Rugby | 2021/06/12 14:00 | Exeter Chiefs v Sale Sharks | W | 20-19 |
Away History
| Premiership Rugby | 2021/10/17 14:00 | London Irish v Gloucester | D | 25-25 |
| Premiership Rugby | 2021/10/09 14:00 | London Irish v Leicester | L | 16-21 |
| Premiership Rugby | 2021/10/02 13:00 | Northampton v London Irish | L | 23-21 |
| Premiership Rugby | 2021/09/26 14:00 | London Irish v Sale Sharks | D | 31-31 |
| Premiership Rugby | 2021/09/18 14:00 | Worcester Warriors v London Irish | L | 36-24 |
| Premiership Rugby | 2021/06/05 15:30 | London Irish v Wasps | L | 36-39 |
| Premiership Rugby | 2021/05/28 18:45 | Gloucester v London Irish | L | 30-28 |
| Premiership Rugby | 2021/05/18 18:45 | London Irish v Exeter Chiefs | L | 12-31 |