[4] Northampton 32-31 Harlequins [3] 2022-04-29 18:45
Stadium: Franklin's Gardens Round: 24
Referee: Matthew Carley
Head to Head
| Premiership Rugby | 2021/12/27 17:00 | Harlequins v Northampton | L | 41-27 |
| Premiership Rugby Cup | 2021/11/19 19:45 | Harlequins v Northampton | L | 26-25 |
| Premiership Rugby | 2021/03/07 15:00 | Harlequins v Northampton | L | 37-19 |
| Premiership Rugby | 2020/11/28 14:00 | Northampton v Harlequins | L | 29-49 |
| Premiership Rugby | 2020/08/30 13:00 | Harlequins v Northampton | L | 30-17 |
| Premiership Rugby | 2019/11/01 19:45 | Northampton v Harlequins | W | 40-22 |
| Premiership Rugby | 2019/04/13 14:00 | Harlequins v Northampton | W | 19-20 |
| Premiership Rugby | 2018/09/07 18:45 | Northampton v Harlequins | W | 25-18 |
Home History
| Premiership Rugby | 2022/04/23 14:00 | Bath v Northampton | W | 31-36 |
| European Rugby Challenge Cup | 2022/04/16 19:00 | Gloucester v Northampton | L | 31-21 |
| Premiership Rugby | 2022/04/02 14:00 | Northampton v Bristol | W | 39-22 |
| Premiership Rugby Cup | 2022/03/30 18:45 | Northampton v Newcastle Falcons | W | 34-26 |
| Premiership Rugby | 2022/03/26 15:00 | London Irish v Northampton | W | 22-42 |
| Premiership Rugby Cup | 2022/03/19 15:00 | Saracens v Northampton | W | 35-46 |
| Premiership Rugby | 2022/03/13 15:00 | Northampton v Wasps | W | 27-22 |
| Premiership Rugby | 2022/03/05 15:00 | Gloucester v Northampton | L | 35-30 |
Away History
| Premiership Rugby | 2022/04/23 14:00 | Harlequins v Leicester | W | 26-20 |
| European Rugby Champions Cup | 2022/04/16 11:30 | Harlequins v Montpellier | W | 33-20 |
| European Rugby Champions Cup | 2022/04/10 12:00 | Montpellier v Harlequins | L | 40-26 |
| Premiership Rugby | 2022/04/03 14:00 | London Irish v Harlequins | W | 14-41 |
| Premiership Rugby Cup | 2022/03/29 18:45 | Harlequins v Sale Sharks | L | 29-34 |
| Premiership Rugby Cup | 2022/03/18 19:45 | London Irish v Harlequins | L | 34-19 |
| Premiership Rugby | 2022/03/13 15:00 | Bristol v Harlequins | W | 29-38 |
| Premiership Rugby | 2022/03/04 19:45 | Harlequins v Newcastle Falcons | W | 24-10 |