| Panama Liga Prom | 2021/03/27 22:00 | Mario Mendez FC v San Francisco Reserves | L | 1-0 |
| Panama Liga Prom | 2021/09/10 21:00 | Veraguas CD Reserves v San Francisco Reserves | W | 0-1 |
| Panama Liga Prom | 2021/09/04 00:00 | SD Panama Oeste v San Francisco Reserves | L | 2-1 |
| Panama Liga Prom | 2021/08/28 22:00 | San Francisco Reserves v CA Independiente de la Chorrera Reserves | D | 0-0 |
| Panama Liga Prom | 2021/08/19 20:00 | Udelas FC v San Francisco Reserves | W | 2-3 |
| Panama Liga Prom | 2021/08/13 20:00 | San Francisco Reserves v SD Atletico Nacional | L | 1-2 |
| Panama Liga Prom | 2021/08/07 22:00 | Aguilas de la U v San Francisco Reserves | D | 2-2 |
| Panama Liga Prom | 2021/05/07 20:00 | SD Panama Oeste v San Francisco Reserves | L | 4-1 |
| Panama Liga Prom | 2021/05/01 20:00 | San Francisco Reserves v CA Independiente de la Chorrera Reserves | L | 1-4 |
| Panama Liga Prom | 2021/09/10 23:00 | Mario Mendez FC v Aguilas de la U | W | 1-0 |
| Panama Liga Prom | 2021/08/28 22:00 | Mario Mendez FC v Herrera FC Reserves | W | 3-0 |
| Panama Liga Prom | 2021/08/15 22:00 | Mario Mendez FC v CD Universitario Reserves | D | 1-1 |
| Panama Liga Prom | 2021/08/08 22:00 | Atletico Chiriqui B v Mario Mendez FC | W | 0-1 |
| Panama Liga Prom | 2021/06/06 22:00 | Alianza FC Reserves v Mario Mendez FC | L | 2-1 |
| Panama Liga Prom | 2021/05/29 00:00 | SD Atletico Nacional v Mario Mendez FC | D | 2-2 |
| Panama Liga Prom | 2021/05/22 20:00 | Mario Mendez FC v CA Independiente de la Chorrera Reserves | W | 8-7 |
| Panama Liga Prom | 2021/05/15 00:00 | CA Independiente de la Chorrera Reserves v Mario Mendez FC | D | 0-0 |