Grambling State 0-45 Houston 2021-09-18 23:00
Stadium: Space City Financial Stadium Round: 1
Home Manager: Dana Holgorsen Away Manager: Broderick Fobbs
Head to Head
| NCAAF | 2014/09/07 00:00 | Houston v Grambling State | L | 47-0 |
| NCAAF | 2006/09/16 12:00 | Houston v Grambling State | L | 42-22 |
Home History
| NCAAF | 2021/09/11 23:00 | Grambling State v Southern Mississippi | L | 0-37 |
| NCAAF | 2021/09/05 20:00 | Grambling State v Tennessee State | W | 16-10 |
| NCAAF | 2021/04/17 18:30 | Grambling State v Southern | L | 7-49 |
| NCAAF | 2021/03/20 17:00 | Arkansas Pine Bluff v Grambling State | L | 48-21 |
| NCAAF | 2021/03/13 21:00 | Prairie View v Grambling State | L | 17-10 |
| NCAAF | 2021/03/06 18:00 | Jackson State v Grambling State | L | 33-28 |
| NCAAF | 2019/11/30 22:00 | Southern v Grambling State | L | 30-28 |
| NCAAF | 2019/11/16 19:00 | Grambling State v Mississippi Valley State | W | 40-0 |
Away History
| NCAAF | 2021/09/11 22:30 | Houston v Rice | W | 44-7 |
| NCAAF | 2021/09/04 23:00 | Texas Tech v Houston | L | 38-21 |
| NCAAF | 2020/12/24 20:30 | Hawaii v Houston | L | 28-14 |
| NCAAF | 2020/12/12 20:45 | Houston v Memphis | L | 27-30 |
| NCAAF | 2020/11/14 20:30 | South Florida v Houston | W | 21-56 |
| NCAAF | 2020/11/07 20:30 | Houston v Cincinnati | L | 10-38 |
| NCAAF | 2020/10/31 18:00 | Central Florida v Houston | L | 44-21 |
| NCAAF | 2020/10/24 19:30 | Houston v Navy | W | 37-21 |