[25] Kentucky 16-10 South Carolina [65] 2021-09-25 23:00
Stadium: Williams-Brice Stadium Round: 1
Home Manager: Shane Beamer Away Manager: Mark Stoops
Head to Head
| NCAAF | 2020/12/06 00:30 | South Carolina v Kentucky | W | 18-41 |
| NCAAF | 2019/09/28 23:30 | Kentucky v South Carolina | L | 7-24 |
| NCAAF | 2018/09/29 23:30 | South Carolina v Kentucky | W | 10-24 |
| NCAAF | 2017/09/16 23:30 | South Carolina v Kentucky | W | 13-23 |
| NCAAF | 2016/09/24 23:30 | South Carolina v Kentucky | W | 10-17 |
| NCAAF | 2015/09/12 23:30 | South Carolina v Kentucky | W | 22-26 |
| NCAAF | 2014/10/04 23:30 | Kentucky v South Carolina | W | 45-38 |
| NCAAF | 2012/09/29 12:00 | Kentucky v South Carolina | L | 17-38 |
Home History
| NCAAF | 2021/09/18 16:00 | Tennessee Chattanooga v Kentucky | W | 23-28 |
| NCAAF | 2021/09/11 23:30 | Missouri v Kentucky | W | 28-35 |
| NCAAF | 2021/09/04 16:00 | UL Monroe v Kentucky | W | 10-45 |
| NCAAF | 2021/01/02 17:00 | Kentucky v NC State | W | 23-21 |
| NCAAF | 2020/12/06 00:30 | South Carolina v Kentucky | W | 18-41 |
| NCAAF | 2020/11/28 17:00 | Kentucky v Florida | L | 10-34 |
| NCAAF | 2020/11/21 21:00 | Kentucky v Alabama | L | 3-63 |
| NCAAF | 2020/11/14 17:00 | Vanderbilt v Kentucky | W | 35-38 |
Away History
| NCAAF | 2021/09/18 23:00 | South Carolina v Georgia | L | 13-40 |
| NCAAF | 2021/09/11 16:00 | South Carolina v East Carolina | W | 20-17 |
| NCAAF | 2021/09/04 23:00 | Eastern Illinois v South Carolina | W | 0-46 |
| NCAAF | 2020/12/06 00:30 | South Carolina v Kentucky | L | 18-41 |
| NCAAF | 2020/11/29 00:30 | Georgia v South Carolina | L | 45-16 |
| NCAAF | 2020/11/22 00:30 | Missouri v South Carolina | L | 17-10 |
| NCAAF | 2020/11/15 00:30 | South Carolina v Mississippi | L | 42-59 |
| NCAAF | 2020/11/08 00:00 | Texas A&M v South Carolina | L | 48-3 |