[7] BOS Bruins 4-1 BUF Sabres [2] 2021-10-22 23:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Bruce Cassidy
Head to Head
| NHL | 2021/05/01 17:00 | BUF Sabres v BOS Bruins | W | 2-6 |
| NHL | 2021/04/29 23:00 | BUF Sabres v BOS Bruins | W | 2-5 |
| NHL | 2021/04/23 23:00 | BOS Bruins v BUF Sabres | L | 4-6 |
| NHL | 2021/04/22 23:00 | BOS Bruins v BUF Sabres | W | 5-1 |
| NHL | 2021/04/20 22:30 | BOS Bruins v BUF Sabres | W | 2-0 |
| NHL | 2021/04/13 23:00 | BUF Sabres v BOS Bruins | W | 2-3 |
| NHL | 2021/03/27 17:00 | BUF Sabres v BOS Bruins | W | 2-3 |
| NHL | 2021/03/18 23:00 | BOS Bruins v BUF Sabres | W | 4-1 |
Home History
| NHL | 2021/10/20 23:30 | BOS Bruins v PHI Flyers | L | 3-6 |
| NHL | 2021/10/16 23:00 | DAL Stars v BOS Bruins | W | 1-3 |
| NHL Pre-Season | 2021/10/06 23:00 | WAS Capitals v BOS Bruins | L | 4-3 |
| NHL Pre-Season | 2021/10/04 23:00 | BOS Bruins v PHI Flyers | L | 1-2 |
| NHL Pre-Season | 2021/10/02 23:00 | NY Rangers v BOS Bruins | L | 4-3 |
| NHL Pre-Season | 2021/09/30 23:30 | PHI Flyers v BOS Bruins | W | 2-4 |
| NHL Pre-Season | 2021/09/28 23:00 | BOS Bruins v NY Rangers | L | 2-3 |
| NHL Pre-Season | 2021/09/26 21:00 | BOS Bruins v WAS Capitals | W | 3-2 |
Away History
| NHL | 2021/10/19 23:00 | VAN Canucks v BUF Sabres | W | 2-5 |
| NHL | 2021/10/16 17:00 | ARZ Coyotes v BUF Sabres | W | 1-2 |
| NHL | 2021/10/14 23:00 | MON Canadiens v BUF Sabres | W | 1-5 |
| NHL Pre-Season | 2021/10/09 19:00 | DET Red Wings v BUF Sabres | W | 1-3 |
| NHL Pre-Season | 2021/10/05 23:00 | BUF Sabres v PIT Penguins | L | 4-5 |
| NHL Pre-Season | 2021/10/04 23:00 | CLB Blue Jackets v BUF Sabres | L | 5-3 |
| NHL Pre-Season | 2021/10/01 23:00 | PIT Penguins v BUF Sabres | L | 2-1 |
| NHL Pre-Season | 2021/09/30 23:30 | BUF Sabres v DET Red Wings | L | 2-6 |