[5] TB Lightning 1-5 BUF Sabres [2] 2021-10-25 23:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Jon Cooper
Head to Head
| NHL | 2020/01/01 00:00 | TB Lightning v BUF Sabres | W | 6-4 |
| NHL | 2019/11/26 00:00 | BUF Sabres v TB Lightning | W | 2-5 |
| NHL | 2019/11/09 18:00 | BUF Sabres v TB Lightning | W | 3-5 |
| NHL | 2019/11/08 19:00 | TB Lightning v BUF Sabres | W | 3-2 |
| NHL | 2019/02/22 00:30 | BUF Sabres v TB Lightning | W | 1-2 |
| NHL | 2019/01/13 00:00 | TB Lightning v BUF Sabres | W | 5-3 |
| NHL | 2018/11/30 00:30 | BUF Sabres v TB Lightning | W | 4-5 |
| NHL | 2018/11/14 00:30 | TB Lightning v BUF Sabres | L | 1-2 |
Home History
| NHL | 2021/10/23 23:00 | COL Avalanche v TB Lightning | L | 4-3 |
| NHL | 2021/10/19 23:00 | FLA Panthers v TB Lightning | L | 4-1 |
| NHL | 2021/10/16 23:00 | TB Lightning v WAS Capitals | W | 2-1 |
| NHL | 2021/10/14 23:30 | TB Lightning v DET Red Wings | W | 7-6 |
| NHL | 2021/10/12 23:30 | PIT Penguins v TB Lightning | L | 6-2 |
| NHL Pre-Season | 2021/10/09 22:00 | TB Lightning v FLA Panthers | W | 4-2 |
| NHL Pre-Season | 2021/10/07 23:00 | FLA Panthers v TB Lightning | W | 2-6 |
| NHL Pre-Season | 2021/10/05 23:00 | FLA Panthers v TB Lightning | L | 3-2 |
Away History
| NHL | 2021/10/23 23:00 | BUF Sabres v NJ Devils | L | 1-2 |
| NHL | 2021/10/22 23:00 | BOS Bruins v BUF Sabres | L | 4-1 |
| NHL | 2021/10/19 23:00 | VAN Canucks v BUF Sabres | W | 2-5 |
| NHL | 2021/10/16 17:00 | ARZ Coyotes v BUF Sabres | W | 1-2 |
| NHL | 2021/10/14 23:00 | MON Canadiens v BUF Sabres | W | 1-5 |
| NHL Pre-Season | 2021/10/09 19:00 | DET Red Wings v BUF Sabres | W | 1-3 |
| NHL Pre-Season | 2021/10/05 23:00 | BUF Sabres v PIT Penguins | L | 4-5 |
| NHL Pre-Season | 2021/10/04 23:00 | CLB Blue Jackets v BUF Sabres | L | 5-3 |