[3] BUF Sabres 4-3 ANA Ducks [7] 2021-10-29 02:00
Stadium: Honda Center
Home Manager: Dallas Eakins Away Manager: Don Granato
Head to Head
| NHL | 2020/02/09 20:00 | ANA Ducks v BUF Sabres | L | 3-2 |
| NHL | 2019/10/17 02:00 | BUF Sabres v ANA Ducks | L | 2-5 |
| NHL | 2018/12/23 00:00 | ANA Ducks v BUF Sabres | W | 0-3 |
| NHL | 2018/10/22 00:00 | BUF Sabres v ANA Ducks | W | 4-2 |
| NHL | 2018/02/07 00:00 | ANA Ducks v BUF Sabres | L | 4-3 |
| NHL | 2017/10/16 01:00 | BUF Sabres v ANA Ducks | W | 3-1 |
| NHL | 2017/03/18 04:33 | BUF Sabres v ANA Ducks | D | 2-2 |
| NHL | 2017/03/18 02:00 | ANA Ducks v BUF Sabres | W | 1-2 |
Home History
| NHL | 2021/10/25 23:00 | TB Lightning v BUF Sabres | W | 1-5 |
| NHL | 2021/10/23 23:00 | BUF Sabres v NJ Devils | L | 1-2 |
| NHL | 2021/10/22 23:00 | BOS Bruins v BUF Sabres | L | 4-1 |
| NHL | 2021/10/19 23:00 | VAN Canucks v BUF Sabres | W | 2-5 |
| NHL | 2021/10/16 17:00 | ARZ Coyotes v BUF Sabres | W | 1-2 |
| NHL | 2021/10/14 23:00 | MON Canadiens v BUF Sabres | W | 1-5 |
| NHL Pre-Season | 2021/10/09 19:00 | DET Red Wings v BUF Sabres | W | 1-3 |
| NHL Pre-Season | 2021/10/05 23:00 | BUF Sabres v PIT Penguins | L | 4-5 |
Away History
| NHL | 2021/10/27 02:00 | WIN Jets v ANA Ducks | L | 4-3 |
| NHL | 2021/10/23 22:00 | ANA Ducks v MIN Wild | L | 3-4 |
| NHL | 2021/10/22 00:00 | ANA Ducks v WIN Jets | L | 1-5 |
| NHL | 2021/10/20 01:00 | ANA Ducks v EDM Oilers | L | 5-6 |
| NHL | 2021/10/19 01:30 | ANA Ducks v CAL Flames | W | 3-2 |
| NHL | 2021/10/16 02:00 | MIN Wild v ANA Ducks | L | 2-1 |
| NHL | 2021/10/14 02:00 | WIN Jets v ANA Ducks | W | 1-4 |
| NHL Pre-Season | 2021/10/10 02:30 | ANA Ducks v LA Kings | W | 4-3 |