[6] BUF Sabres 4-5 NY Rangers [5] 2021-11-21 23:00
Stadium: Madison Square Garden
Home Manager: Gerard Gallant Away Manager: Don Granato
Head to Head
| NHL | 2021/04/27 23:00 | BUF Sabres v NY Rangers | L | 1-3 |
| NHL | 2021/04/25 22:00 | BUF Sabres v NY Rangers | L | 3-6 |
| NHL | 2021/04/03 23:00 | NY Rangers v BUF Sabres | W | 2-3 |
| NHL | 2021/04/01 23:00 | NY Rangers v BUF Sabres | L | 3-2 |
| NHL | 2021/03/22 23:00 | BUF Sabres v NY Rangers | L | 3-5 |
| NHL | 2021/03/03 00:00 | BUF Sabres v NY Rangers | L | 2-3 |
| NHL | 2021/01/29 00:00 | NY Rangers v BUF Sabres | L | 3-2 |
| NHL | 2021/01/27 00:00 | NY Rangers v BUF Sabres | W | 2-3 |
Home History
| NHL | 2021/11/19 00:00 | CAL Flames v BUF Sabres | L | 5-0 |
| NHL | 2021/11/17 00:00 | BUF Sabres v PIT Penguins | W | 2-1 |
| NHL | 2021/11/14 00:00 | TOR Maple Leafs v BUF Sabres | L | 5-4 |
| NHL | 2021/11/13 00:00 | EDM Oilers v BUF Sabres | W | 2-3 |
| NHL | 2021/11/09 00:00 | BUF Sabres v WAS Capitals | L | 3-5 |
| NHL | 2021/11/06 23:00 | DET Red Wings v BUF Sabres | L | 4-3 |
| NHL | 2021/11/05 02:00 | BUF Sabres v SEA Kraken | L | 2-5 |
| NHL | 2021/11/03 02:30 | BUF Sabres v SJ Sharks | L | 3-5 |
Away History
| NHL | 2021/11/19 00:00 | NY Rangers v TOR Maple Leafs | L | 1-2 |
| NHL | 2021/11/17 00:00 | MON Canadiens v NY Rangers | W | 2-3 |
| NHL | 2021/11/15 00:00 | NJ Devils v NY Rangers | W | 3-4 |
| NHL | 2021/11/14 00:00 | NY Rangers v CLB Blue Jackets | W | 5-3 |
| NHL | 2021/11/09 00:00 | FLA Panthers v NY Rangers | W | 3-4 |
| NHL | 2021/11/07 02:00 | NY Rangers v CAL Flames | L | 0-6 |
| NHL | 2021/11/06 01:30 | NY Rangers v EDM Oilers | L | 5-6 |
| NHL | 2021/11/03 02:00 | NY Rangers v VAN Canucks | L | 2-3 |