[11] CLB Blue Jackets 7-4 BUF Sabres [6] 2021-11-23 00:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Brad Larsen
Head to Head
| NHL Pre-Season | 2021/10/04 23:00 | CLB Blue Jackets v BUF Sabres | W | 5-3 |
| NHL Pre-Season | 2021/09/28 23:00 | BUF Sabres v CLB Blue Jackets | L | 5-4 |
| NHL | 2020/02/14 00:00 | CLB Blue Jackets v BUF Sabres | L | 3-4 |
| NHL | 2020/02/01 18:00 | CLB Blue Jackets v BUF Sabres | L | 1-2 |
| NHL | 2019/10/07 23:00 | BUF Sabres v CLB Blue Jackets | W | 3-4 |
| NHL Pre-Season | 2019/09/25 23:00 | CLB Blue Jackets v BUF Sabres | L | 3-4 |
| NHL Pre-Season | 2019/09/17 23:00 | BUF Sabres v CLB Blue Jackets | W | 1-4 |
| NHL | 2019/03/31 22:00 | CLB Blue Jackets v BUF Sabres | W | 4-0 |
Home History
| NHL | 2021/11/21 03:00 | CLB Blue Jackets v VGS Golden Knights | L | 2-3 |
| NHL | 2021/11/19 02:00 | CLB Blue Jackets v ARZ Coyotes | W | 5-4 |
| NHL | 2021/11/16 00:00 | DET Red Wings v CLB Blue Jackets | W | 3-5 |
| NHL | 2021/11/14 00:00 | NY Rangers v CLB Blue Jackets | L | 5-3 |
| NHL | 2021/11/13 00:00 | WAS Capitals v CLB Blue Jackets | L | 4-3 |
| NHL | 2021/11/06 23:00 | COL Avalanche v CLB Blue Jackets | W | 2-4 |
| NHL | 2021/11/04 01:00 | CLB Blue Jackets v COL Avalanche | W | 5-4 |
| NHL | 2021/10/31 21:00 | CLB Blue Jackets v NJ Devils | W | 4-3 |
Away History
| NHL | 2021/11/21 23:00 | BUF Sabres v NY Rangers | L | 4-5 |
| NHL | 2021/11/19 00:00 | CAL Flames v BUF Sabres | L | 5-0 |
| NHL | 2021/11/17 00:00 | BUF Sabres v PIT Penguins | W | 2-1 |
| NHL | 2021/11/14 00:00 | TOR Maple Leafs v BUF Sabres | L | 5-4 |
| NHL | 2021/11/13 00:00 | EDM Oilers v BUF Sabres | W | 2-3 |
| NHL | 2021/11/09 00:00 | BUF Sabres v WAS Capitals | L | 3-5 |
| NHL | 2021/11/06 23:00 | DET Red Wings v BUF Sabres | L | 4-3 |
| NHL | 2021/11/05 02:00 | BUF Sabres v SEA Kraken | L | 2-5 |