[7] CLB Blue Jackets 3-6 STL Blues [3] 2021-11-28 01:00
Stadium: Enterprise Center
Home Manager: Craig Berube Away Manager: Brad Larsen
Head to Head
| NHL Pre-Season | 2021/10/09 00:00 | CLB Blue Jackets v STL Blues | L | 3-7 |
| NHL Pre-Season | 2021/09/29 23:00 | STL Blues v CLB Blue Jackets | W | 2-5 |
| NHL | 2019/11/16 00:00 | STL Blues v CLB Blue Jackets | W | 2-3 |
| NHL | 2019/11/02 00:00 | CLB Blue Jackets v STL Blues | L | 3-4 |
| NHL Pre-Season | 2019/09/22 19:30 | CLB Blue Jackets v STL Blues | L | 3-5 |
| NHL | 2019/02/03 00:00 | STL Blues v CLB Blue Jackets | L | 4-2 |
| NHL | 2018/10/26 00:00 | CLB Blue Jackets v STL Blues | W | 7-4 |
| NHL Pre-Season | 2018/09/23 19:00 | STL Blues v CLB Blue Jackets | L | 5-1 |
Home History
| NHL | 2021/11/27 00:00 | VAN Canucks v CLB Blue Jackets | W | 2-4 |
| NHL | 2021/11/25 00:00 | WIN Jets v CLB Blue Jackets | W | 0-3 |
| NHL | 2021/11/23 00:00 | CLB Blue Jackets v BUF Sabres | W | 7-4 |
| NHL | 2021/11/21 03:00 | CLB Blue Jackets v VGS Golden Knights | L | 2-3 |
| NHL | 2021/11/19 02:00 | CLB Blue Jackets v ARZ Coyotes | W | 5-4 |
| NHL | 2021/11/16 00:00 | DET Red Wings v CLB Blue Jackets | W | 3-5 |
| NHL | 2021/11/14 00:00 | NY Rangers v CLB Blue Jackets | L | 5-3 |
| NHL | 2021/11/13 00:00 | WAS Capitals v CLB Blue Jackets | L | 4-3 |
Away History
| NHL | 2021/11/26 20:30 | STL Blues v CHI Blackhawks | L | 2-3 |
| NHL | 2021/11/25 00:30 | STL Blues v DET Red Wings | L | 2-4 |
| NHL | 2021/11/23 01:00 | VGS Golden Knights v STL Blues | W | 2-5 |
| NHL | 2021/11/21 01:00 | STL Blues v DAL Stars | L | 1-4 |
| NHL | 2021/11/19 01:00 | SJ Sharks v STL Blues | W | 1-4 |
| NHL | 2021/11/17 01:00 | ARZ Coyotes v STL Blues | L | 3-2 |
| NHL | 2021/11/15 00:00 | EDM Oilers v STL Blues | L | 5-4 |
| NHL | 2021/11/14 00:30 | STL Blues v CAR Hurricanes | L | 2-3 |