DET Red Wings 1-3 BUF Sabres 2021-10-09 19:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Jeff Blashill
Head to Head
| NHL Pre-Season | 2021/09/30 23:30 | BUF Sabres v DET Red Wings | W | 2-6 |
| NHL | 2020/02/12 00:00 | DET Red Wings v BUF Sabres | L | 2-3 |
| NHL | 2020/02/07 00:00 | DET Red Wings v BUF Sabres | W | 4-3 |
| NHL | 2020/01/12 22:00 | BUF Sabres v DET Red Wings | L | 5-1 |
| NHL | 2019/10/25 23:30 | BUF Sabres v DET Red Wings | L | 2-0 |
| NHL | 2019/04/06 23:00 | BUF Sabres v DET Red Wings | L | 7-1 |
| NHL | 2019/03/28 23:00 | DET Red Wings v BUF Sabres | W | 5-4 |
| NHL | 2019/02/09 18:00 | DET Red Wings v BUF Sabres | L | 1-3 |
Home History
| NHL Pre-Season | 2021/10/07 23:30 | PIT Penguins v DET Red Wings | W | 2-4 |
| NHL Pre-Season | 2021/10/06 23:00 | DET Red Wings v CLB Blue Jackets | L | 2-4 |
| NHL Pre-Season | 2021/10/04 23:30 | CHI Blackhawks v DET Red Wings | L | 6-4 |
| NHL Pre-Season | 2021/10/03 16:00 | DET Red Wings v PIT Penguins | L | 1-5 |
| NHL Pre-Season | 2021/10/02 23:00 | CLB Blue Jackets v DET Red Wings | W | 1-5 |
| NHL Pre-Season | 2021/09/30 23:30 | BUF Sabres v DET Red Wings | W | 2-6 |
| NHL Pre-Season | 2021/09/30 00:30 | DET Red Wings v CHI Blackhawks | W | 4-3 |
| NHL | 2021/05/08 23:00 | DET Red Wings v CLB Blue Jackets | L | 4-5 |
Away History
| NHL Pre-Season | 2021/10/05 23:00 | BUF Sabres v PIT Penguins | L | 4-5 |
| NHL Pre-Season | 2021/10/04 23:00 | CLB Blue Jackets v BUF Sabres | L | 5-3 |
| NHL Pre-Season | 2021/10/01 23:00 | PIT Penguins v BUF Sabres | L | 2-1 |
| NHL Pre-Season | 2021/09/30 23:30 | BUF Sabres v DET Red Wings | L | 2-6 |
| NHL Pre-Season | 2021/09/28 23:00 | BUF Sabres v CLB Blue Jackets | W | 5-4 |
| NHL | 2021/05/08 19:00 | BUF Sabres v PIT Penguins | L | 0-1 |
| NHL | 2021/05/06 23:00 | BUF Sabres v PIT Penguins | L | 4-8 |
| NHL | 2021/05/04 23:00 | NY Islanders v BUF Sabres | W | 3-4 |