BUF Sabres 4-5 PIT Penguins 2021-10-05 23:00
Stadium: PPG Paints Arena
Home Manager: Mike Sullivan Away Manager: Don Granato
Head to Head
| NHL Pre-Season | 2021/10/01 23:00 | PIT Penguins v BUF Sabres | L | 2-1 |
| NHL | 2021/05/08 19:00 | BUF Sabres v PIT Penguins | L | 0-1 |
| NHL | 2021/05/06 23:00 | BUF Sabres v PIT Penguins | L | 4-8 |
| NHL | 2021/04/18 19:00 | PIT Penguins v BUF Sabres | W | 2-4 |
| NHL | 2021/04/17 19:00 | PIT Penguins v BUF Sabres | L | 3-2 |
| NHL | 2021/03/25 23:00 | BUF Sabres v PIT Penguins | L | 0-4 |
| NHL | 2021/03/25 00:00 | BUF Sabres v PIT Penguins | L | 2-5 |
| NHL | 2021/03/14 00:00 | PIT Penguins v BUF Sabres | L | 3-0 |
Home History
| NHL Pre-Season | 2021/10/04 23:00 | CLB Blue Jackets v BUF Sabres | L | 5-3 |
| NHL Pre-Season | 2021/10/01 23:00 | PIT Penguins v BUF Sabres | L | 2-1 |
| NHL Pre-Season | 2021/09/30 23:30 | BUF Sabres v DET Red Wings | L | 2-6 |
| NHL Pre-Season | 2021/09/28 23:00 | BUF Sabres v CLB Blue Jackets | W | 5-4 |
| NHL | 2021/05/08 19:00 | BUF Sabres v PIT Penguins | L | 0-1 |
| NHL | 2021/05/06 23:00 | BUF Sabres v PIT Penguins | L | 4-8 |
| NHL | 2021/05/04 23:00 | NY Islanders v BUF Sabres | W | 3-4 |
| NHL | 2021/05/03 23:00 | NY Islanders v BUF Sabres | W | 2-4 |
Away History
| NHL Pre-Season | 2021/10/03 16:00 | DET Red Wings v PIT Penguins | W | 1-5 |
| NHL Pre-Season | 2021/10/01 23:00 | PIT Penguins v BUF Sabres | W | 2-1 |
| NHL Pre-Season | 2021/09/27 23:00 | CLB Blue Jackets v PIT Penguins | L | 3-0 |
| NHL | 2021/05/26 22:30 | PIT Penguins v NY Islanders | L | 3-5 |
| NHL | 2021/05/24 23:00 | NY Islanders v PIT Penguins | L | 3-2 |
| NHL | 2021/05/22 19:00 | PIT Penguins v NY Islanders | L | 1-4 |
| NHL | 2021/05/20 23:00 | PIT Penguins v NY Islanders | W | 5-4 |
| NHL | 2021/05/18 23:30 | NY Islanders v PIT Penguins | W | 1-2 |