[25] NY Islanders 1-4 TB Lightning [17] 2021-11-16 00:00
Stadium: Amalie Arena
Home Manager: Jon Cooper Away Manager: Barry Trotz
Head to Head
| NHL | 2021/06/26 00:00 | NY Islanders v TB Lightning | L | 0-1 |
| NHL | 2021/06/24 00:00 | TB Lightning v NY Islanders | W | 2-3 |
| NHL | 2021/06/22 00:00 | NY Islanders v TB Lightning | L | 0-8 |
| NHL | 2021/06/20 00:00 | TB Lightning v NY Islanders | W | 2-3 |
| NHL | 2021/06/18 00:00 | TB Lightning v NY Islanders | L | 2-1 |
| NHL | 2021/06/16 00:00 | NY Islanders v TB Lightning | L | 2-4 |
| NHL | 2021/06/13 19:00 | NY Islanders v TB Lightning | W | 2-1 |
| NHL | 2020/09/18 00:00 | TB Lightning v NY Islanders | L | 2-1 |
Home History
| NHL | 2021/11/12 00:00 | NY Islanders v NJ Devils | L | 0-4 |
| NHL | 2021/11/08 01:00 | NY Islanders v MIN Wild | L | 2-5 |
| NHL | 2021/11/06 23:00 | NY Islanders v WIN Jets | W | 2-0 |
| NHL | 2021/11/04 23:00 | NY Islanders v MON Canadiens | W | 6-2 |
| NHL | 2021/10/30 17:30 | NY Islanders v NAS Predators | L | 2-3 |
| NHL | 2021/10/25 02:00 | NY Islanders v VGS Golden Knights | W | 2-0 |
| NHL | 2021/10/24 01:00 | NY Islanders v ARZ Coyotes | W | 3-0 |
| NHL | 2021/10/21 23:00 | NY Islanders v CLB Blue Jackets | L | 2-3 |
Away History
| NHL | 2021/11/14 00:00 | FLA Panthers v TB Lightning | W | 2-3 |
| NHL | 2021/11/10 00:00 | CAR Hurricanes v TB Lightning | L | 2-1 |
| NHL | 2021/11/06 18:00 | TB Lightning v OTT Senators | W | 5-3 |
| NHL | 2021/11/04 23:00 | TB Lightning v TOR Maple Leafs | L | 1-2 |
| NHL | 2021/11/01 23:00 | WAS Capitals v TB Lightning | W | 2-3 |
| NHL | 2021/10/28 23:00 | ARZ Coyotes v TB Lightning | W | 1-5 |
| NHL | 2021/10/26 23:00 | TB Lightning v PIT Penguins | W | 5-1 |
| NHL | 2021/10/25 23:00 | TB Lightning v BUF Sabres | L | 1-5 |