[4] DET Red Wings 2-1 BOS Bruins [5] 2021-12-01 00:00
Stadium: TD Garden
Home Manager: Bruce Cassidy Away Manager: Jeff Blashill
Head to Head
| NHL | 2021/11/04 23:00 | DET Red Wings v BOS Bruins | L | 1-5 |
| NHL | 2020/02/15 18:00 | DET Red Wings v BOS Bruins | L | 1-4 |
| NHL | 2020/02/09 17:30 | BOS Bruins v DET Red Wings | W | 1-3 |
| NHL | 2019/11/09 00:30 | BOS Bruins v DET Red Wings | W | 2-4 |
| NHL | 2019/03/31 23:30 | BOS Bruins v DET Red Wings | W | 3-6 |
| NHL | 2018/12/02 00:00 | DET Red Wings v BOS Bruins | W | 4-2 |
| NHL | 2018/11/22 00:30 | BOS Bruins v DET Red Wings | W | 2-3 |
| NHL | 2018/10/13 19:00 | DET Red Wings v BOS Bruins | L | 2-8 |
Home History
| NHL | 2021/11/28 00:00 | BUF Sabres v DET Red Wings | W | 2-3 |
| NHL | 2021/11/25 00:30 | STL Blues v DET Red Wings | W | 2-4 |
| NHL | 2021/11/21 01:00 | DET Red Wings v ARZ Coyotes | L | 1-2 |
| NHL | 2021/11/19 03:00 | DET Red Wings v VGS Golden Knights | L | 2-5 |
| NHL | 2021/11/17 01:30 | DET Red Wings v DAL Stars | L | 2-5 |
| NHL | 2021/11/16 00:00 | DET Red Wings v CLB Blue Jackets | L | 3-5 |
| NHL | 2021/11/14 00:00 | MON Canadiens v DET Red Wings | W | 2-3 |
| NHL | 2021/11/12 00:30 | WAS Capitals v DET Red Wings | L | 2-0 |
Away History
| NHL | 2021/11/29 00:00 | VAN Canucks v BOS Bruins | W | 2-3 |
| NHL | 2021/11/26 18:00 | NY Rangers v BOS Bruins | L | 5-2 |
| NHL | 2021/11/25 00:00 | BOS Bruins v BUF Sabres | W | 5-1 |
| NHL | 2021/11/22 00:00 | CAL Flames v BOS Bruins | L | 4-0 |
| NHL | 2021/11/21 00:00 | BOS Bruins v PHI Flyers | W | 5-2 |
| NHL | 2021/11/15 00:00 | MON Canadiens v BOS Bruins | W | 2-5 |
| NHL | 2021/11/13 18:00 | BOS Bruins v NJ Devils | W | 5-2 |
| NHL | 2021/11/12 00:00 | EDM Oilers v BOS Bruins | L | 5-3 |